Table 2 Respiratory and metabolic variables in instrumented awake sheep

SaO₂ (%)

   rhAPC

96 ± 3

95 ± 3

98 ± 1

99 ± 1

98 ± 1

98 ± 1

99 ± 1

   LPS

98 ± 0

98 ± 1

98 ± 1

98 ± 1

98 ± 1

97 ± 2

97 ± 2

   LPS + rhAPC

98 ± 0

96 ± 1

98 ± 0

98 ± 1

97 ± 1

97 ± 1

98 ± 1

SvO₂ (%)

   rhAPC

61 ± 4

59 ± 4

61 ± 5

59 ± 5

61 ± 4

61 ± 5

63 ± 4

   LPS

62 ± 3

62 ± 3

69 ± 2* ^†

67 ± 3*

64 ± 3

63 ± 3

61 ± 3

   LPS + rhAPC

63 ± 3

61 ± 3

70 ± 3^†

66 ± 2^†

67 ± 2* ^†

66 ± 2

67 ± 2* ^†

DO₂I (ml/min/m²)

   rhAPC

640 ± 64

649 ± 7

626 ± 85

573 ± 63

614 ± 39

595 ± 72

654 ± 54

   LPS

608 ± 32

585 ± 48

785 ± 53*

763 ± 62*

731 ± 45*

748 ± 70*

751 ± 73*

   LPS + rhAPC

642 ± 52

611 ± 38

802 ± 76* ^†

772 ± 58^†

732 ± 51^†

693 ± 51

704 ± 55

VO₂I (ml^/min/m²)

   rhAPC

225 ± 37

244 ± 26

243 ± 63

222 ± 46

215 ± 28

206 ± 12

218 ± 28

   LPS

226 ± 7

207 ± 11

232 ± 15

234 ± 14

252 ± 19

261 ± 24

277 ± 30

   LPS + rhAPC

229 ± 26

231 ± 22

225 ± 21

249 ± 20

232 ± 17

227 ± 19

227 ± 22

Qs/Qt

   rhAPC

0.12 ± 0.06

0.13 ± 0.06

0.05 ± 0.02

0.04 ± 0.02

0.08 ± 0.02

0.04 ± 0.01

0.02 ± 0.01

   LPS

0.05 ± 0.01

0.11 ± 0.03

0.13 ± 0.03

0.13 ± 0.04

0.12 ± 0.04

0.10 ± 0.04

0.10 ± 0.04

   LPS + rhAPC

0.07 ± 0.01

0.11 ± 0.02

0.10 ± 0.01

0.08 ± 0.03

0.10 ± 0.03

0.09 ± 0.03

0.08 ± 0.03

Arterial pH

   rhAPC

7.50 ± 0.01

7.47 ± 0.01

7.44 ± 0.03

7.44 ± 0.04

7.45 ± 0.03

7.49 ± 0.02

7.48 ± 0.02

   LPS

7.51 ± 0.01

7.55 ± 0.01

7.54 ± 0.01

7.54 ± 0.01

7.52 ± 0.03

7.53 ± 0.03

7.53 ± 0.03

   LPS + rhAPC

7.49 ± 0.02

7.54 ± 0.01*

7.51 ± 0.01

7.49 ± 0.01^†

7.50 ± 0.01^†

7.52 ± 0.01* ^†

7.51 ± 0.01^†

PaCO₂ (kPa)

   rhAPC

33 ± 2

33 ± 1

33 ± 1

34 ± 2

35 ± 1

33 ± 1

33 ± 1

   LPS

36 ± 1

35 ± 3

33 ± 1

33 ± 1

34 ± 1

34 ± 1

35 ± 1

   LPS + rhAPC

36 ± 1

31 ± 2*

32 ± 1*

34 ± 2

36 ± 2^†

35 ± 2^†

35 ± 2^†

Hemoglobin (g/dl)

   rhAPC

9.1 ± 1.2

9.1 ± 1.3

9.2 ± 1.2

8.7 ± 1.0

8.9 ± 1.1

9.2 ± 1.1

9.3 ± 1.1

   LPS

8.7 ± 0.7

10.4 ± 0.6*

10,3 ± 0.7*

9.6 ± 0.6* ^†

9.7 ± 0.7*

9.7 ± 0.6*

9.6 ± 0.7*

   LPS + rhAPC

9.5 ± 0.6

10.8 ± 0.6*

10.2 ± 0.6^†

9.6 ± 0.6^†

9.4 ± 0.5^†

9.3 ± 0.4^†

9.4 ± 0.5^†

Temperature (°C)

   rhAPC

39.4 ± 0.1

39.4 ± 0.1

39.3 ± 0.2

39.4 ± 0.2

39.3 ± 0.2

39.2 ± 0.2

39.1 ± 0.1

   LPS

39.2 ± 0.2

40.8 ± 0.3*

40.2 ± 0.2*

40.3 ± 0.2*

40.5 ± 0.2*

40.3 ± 0.3*

40.1 ± 0.2*

   LPS + rhAPC

39.1 ± 0.1

41.0 ± 0.3*

40.2 ± 0.2* ^†

40.0 ± 0.1* ^†

40.0 ± 0.1* ^†

40.0 ± 0.2* ^†

39.9 ± 0.2* ^†

Antithrombin III plasma concentration (%)

   rhAPC

70 ± 2

74 ± 2

70 ± 2

70 ± 3

   LPS

79 ± 3

71 ± 4*

66 ± 4* ^†

63 ± 4* ^†

   LPS + rhAPC

69 ± 3

69 ± 3

62 ± 3* ^†

58 ± 2* ^†