Figure 9From: Serine/threonine kinase-protein kinase B and extracellular signal-regulated kinase regulate ventilator-induced pulmonary fibrosis after bleomycin-induced acute lung injury: a prospective, controlled animal experimentDifferences in signaling pathway activation of mechanical ventilation with bleomycin. The serine/threonine kinase/protein kinase B (Akt) and extracellular signal-regulated kinase (ERK) 1/2 pathways were involved in high-tidal-volume ventilation-augmented pulmonary fibrosis after bleomycin-induced acute lung injury, type III procollagen mRNA expression, microvascular permeability, and production of murine macrophage inflammatory protein-2 (MIP-2), but not 10 kDa IFNγ-inducible protein (IP-10) production.Back to article page