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Table 1 Hemodynamics in the pretreatment model

From: High-molecular-weight hyaluronan – a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats

 

Systolic blood pressure

Heart rate

Group

Baseline

4 hours

Baseline

4 hours

Control

98 ± 7

85 ± 7

360 ± 7

327 ± 10

Lipopolysaccharide alone

100 ± 7

79 ± 5

436 ± 11

386 ± 11*

Lipopolysaccharide + 1,600 kDa hyaluronan

112 ± 7

96 ± 9

405 ± 64

412 ± 67*

Lipopolysaccharide + 35 kDa hyaluronan

100 ± 8

79 ± 7

369 ± 66

382 ± 65*

  1. There were no statistical differences between groups for systolic blood pressure. In the lipopolysaccharide-exposed groups the heart rate was statistically higher, but there were no statistical differences between treatment groups. *P < 0.05 versus control.