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Figure 5 | Critical Care

Figure 5

From: High-molecular-weight hyaluronan – a possible new treatment for sepsis-induced lung injury: a preclinical study in mechanically ventilated rats

Figure 5

Pretreatment with hyaluronan (1,600 kDa and 35 kDa) inhibited cytokine protein expression. Animals were pretreated with either 1,600 kDa or 35 kDa hyaluronan 18 hours prior to ventilation. Lipopolysaccharide (LPS) (1 mg/kg) was given by arterial injection 1 hour prior to the start of ventilation. After 4 hours of ventilation, animals were sacrificed and the left lung was lavaged. Cytokine protein expression in bronchoalveolar lavage fluid (BAL) when measured by ELISA. Macrophage inflammatory protein-2 (MIP-2) and TNFα protein expression was decreased with high-molecular-weight hyaluronan or low-molecular-weight hyaluronan. (a) MIP-2. (b) TNFα. *P < 0.05 versus control, #P < 0.05 versus LPS. Non-vent, nonventilated.

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Critical Care

ISSN: 1364-8535