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Table 5 Time course of plasma C-reactive protein (mg/L) in all patients and in the three diagnostic categories from admission to day 5

From: Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma, and subarachnoid hemorrhage patients

All

Day 0

Day 1

Day 2

Day 3

Day 4

Day 5

   AOX

49 (0–2,350)

129 (2–359)a

161 (2–364)a

125 (150–399)a,b

100 (16–401)b

80 (14–401)

   Placebo

35 (2–176)

141 (2–341)a

174 (2–410)a

156 (2–360)a,b

114 (2–438)b

82 (3–388)

Cardiac surgery

      

   AOX

59 (2–150)

150 (2–359)a

165 (2–317)a

123 (20–367)a

84 (20–319)b

81 (14–243)

   Placebo

39 (2–176)

142 (37–341)a

177 (53–410)a

158 (44–360)a

117(26–225)b

81 (19–178)

Trauma

      

   AOX

35 (2–158)

126 (4–282)a,b

164 (9–464)a

146 (41–399)a

146 (41–282)a

114 (41–282)a

   Placebo

32 (2–224)

147 (5–327)a,b

201 (46–326)a

174 (34–328)a

161 (21–438)a

117 (34–388)a

Subarachnoid hemorrhage

      

   AOX

32 (0–230)

38 (3–277)

42 (15–184)

67 (16–103)

44 (16–401)

29 (8–401)

   Placebo

10 (2–61)

27 (2–185)

22 (2–179)

16 (2–233)

22 (2–233)

21 (2–163)

  1. Data are presented as median (range). C-reactive protein differed over time in the antioxidant (AOX) and placebo groups (two-factor repeated analysis of variance: time effect P < 0.0001, group effect P = 0.039, and interaction (time*group) P = 0.16 to not significant [NS]). The attenuation of inflammation was most significant in cardiac patients (time effect P < 0.0001, group effect P = 0.41 [NS], and interaction (time*group) P = 0.0075) and in trauma patients (time effect P < 0.0001, group NS, and time*group NS). No significant change over time was observed in subarachnoid hemorrhage patients. The post hoc comparisons were carried out with the Dunnett test (asignificant difference versus baseline within groups) and the Scheffe test (bsignificant difference between groups at the same time).