Figure 1
From: Bronchodilator delivery with metered-dose inhaler during mechanical ventilation
Drug deposition, expressed as a percentage of nominal dose of albuterol from a chlorofluorocarbon formulation (CFC) propelled MDI, in the spacer chamber, the ventilator circuit, the endotracheal tube and on filters at the bronchi under dry (upper panel) and humidified (lower panel) conditions during controlled mechanical ventilation. Under dry conditions 30.4% of the aerosol was deposited at the target sites (bronchi), versus 16.2% in a humidified circuit. RH, relative humidity; S, spacer chamber; VC, ventilator circuit; ET, endotracheal tube; B, filters at the bronchi. From Fink et al [19].