Combined milrinone and enteral metoprolol therapy in patients with septic myocardial depression

Table 3 Organ function variables during the observation period

	Baseline	6 hours	12 hours	24 hours	48 hours	72 hours	96 hours	P value
Patients, number	40	40	39	37	37	35	33
pH	7.36 ± 0.09	7.37 ± 0.06	7.37 ± 0.1	7.38 ± 0.08	7.38 ± 0.07^a	7.4 ± 0.06^a	7.42 ± 0.07^a	<0.001^b
Lactate, mg/dL	22 ± 15	24 ± 14	29 ± 32	14 ± 10^a	12 ± 8^a	11 ± 7^a	10 ± 5^a	<0.001^b
Creatinine, mg/dL	2.3 ± 1.3	NM	NM	2.0 ± 1.0	1.8 ± 0.7	1.7 ± 0.8	1.6 ± 0.7^a	0.02^b
ASAT, IU/L	230 ± 651	NM	NM	143 ± 253	166 ± 320	199 ± 474	153 ± 336	0.97
ALAT, IU/L	128 ± 435	NM	NM	78 ± 222	90 ± 225	101 ± 207	90 ± 157	0.78
Bilirubin, mg/dL	1.7 ± 1.4	NM	NM	1.6 ± 1.3	1.5 ± 1.1	1.5 ± 1.5	1.6 ± 2.2	0.60
C-reactive protein, mg/dL	17.6 ± 8.7	NM	NM	17.8 ± 9.1	15.2 ± 9.3	11.6 ± 8.6	10 ± 8.2	0.001^b
Troponin I, μg/L	8 ± 40	NM	NM	6 ± 21	3 ± 9	3 ± 7	2 ± 5	0.60
Platelet count, 10⁹/L	145 ± 78	NM	NM	132 ± 88	130 ± 106	134 ± 112	133 ± 123	0.95
PaO₂/FiO₂	244 ± 129	NM	NM	243 ± 92	252 ± 102	238 ± 84	262 ± 89	0.87

^aSignificant effects versus baseline. ^bSignificant time effect. Data are presented as mean value ± standard deviation. ALAT, alanine aminotransferase; ASAT, aspartate aminotransferase; FiO₂, inspiratory oxygen tension; NM, not measured; PaO₂, arterial oxygen tension.

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