Table 2 Characteristics of emergency intensive care unit (ICU) admissions of patients with hematologic malignancy
Admissions of ICU survivors (n = 78) | Admissions of ICU nonsurvivors (n = 23) | P value | |
|---|---|---|---|
Age (years) | 47.6 ± 15.6 | 53.7 ± 9.6 | 0.84 |
Male/female (%) | 59.0/41.0 | 65.2/34.8 | 0.59 |
Reason for ICU admission (%) | 0.15 | ||
Sepsis | 47.4 | 56.5 | |
Respiratory failure | 24.4 | 30.4 | |
Cardiovascular failure | 9.0 | 0 | |
Neurological failure | 1.3 | 13.0 | |
Abdominal event | 6.4 | 0 | |
Other | 11.5 | 0 | |
Type of hematological malignancy | 0.51 | ||
Acute myelogenous leukemia | 39 (50%) | 16 (69.6%) | |
Acute lymphoblastic leukemia | 11 (14.1%) | 0 | |
Chronic myelogenous leukemia | 2 (2.6%) | 0 | |
Non-Hodgkin's lymphoma/myeloma | 23 (29.5%) | 6 (26.1%) | |
Hodgkin's lymphoma | 3 (3.9%) | 0 | |
Myelodysplastic syndrome | 0 | 1 (4.4%) | |
Grading of hematological malignancy | 1.0 | ||
High grade | 60 (77%) | 18 (78%) | |
Low grade | 18 (33%) | 5 (22%) | |
Type of treatment (before ICU admission)a | 0.41 | ||
Chemotherapy | 72 (92.3%) | 20 (87.0%) | |
Radiation | 9 (11.5%) | 0 | |
Surgical procedures | 4 (5.1%) | 1 (4.3%) | |
Autologous/allogeneic stem cell transplantation | 9 (11.5%) | 3 (13.0%) | |
Disease stage | 0.87 | ||
Initial diagnosis | 57 (73.1%) | 18 (78.3%) | |
More advanced disease/relapse | 15 (19.2%) | 3 (13.0%) | |
Complete remission | 1 (1.3%) | 0 | |
Chronic disease | 4 (5.1%) | 2 (8.7%) | |
Other/not applicable | 1 (1.3%) | 0 | |
Rate of neutropenia | 59.0% | 60.9% | 1.00 |
ACE-27 0/1/2/3 points (%) | 53.9/21.8/17.9/6.4 | 43.5/21.7/26.1/8.7 | 0.32 |
ACE-27 0 to 1 | 59 (76%) | 15 (65%) | 0.42 |
ACE-27 2 to 3 | 19 (24%) | 8 (35%) | |
SAPS II at ICU admission | 46 (34 to 56) | 76 (63 to 90) | <0.0001 |
Mechanical ventilation (%) | 43.5 | 95.6 | <0.0001 |
Renal replacement therapy (%) | 3.8 | 39.1 | <0.0001 |
ICU length of stay (days) | 2 (1 to 6) | 6 (2 to 11) | 0.02 |