Table 5 Patient characteristics during the intensive care unit stay
Intention to treat | Modified intention to treat | |||||
|---|---|---|---|---|---|---|
Antibiotic treatment n = 22 | No antibiotic treatment n = 36 | P value | Antibiotic treatment n = 18 | No antibiotic treatment n = 26 | P value | |
Tracheostomy | 5 (22) | 5 (13) | >0.999 | 5 (27) | 5 (19) | 0.716 |
Corticosteroid use | 8 (36) | 19 (52) | 0.283 | 6 (33) | 13 (50) | 0.359 |
Septic shock | 1 (4) | 7 (19) | 0.134 | 1 (5) | 5 (19) | 0.375 |
ICU-acquired infections other than VAT and VAPa | 7 (31) | 18 (50) | 0.274 | 6 (33) | 13 (50) | 0.359 |
Bacteremia | 6 (27) | 13 (36) | 0.572 | 5 (27) | 8 (30) | >0.999 |
Urinary tract infection | 2 (9) | 5 (13) | 0.698 | 2 (11) | 5 (19) | 0.682 |
Others | 2 (9) | 2 (5) | >0.999 | 2 (11) | 2 (7) | >0.999 |
Total duration of antibiotic treatment, days | 25 ± 14 | 19 ± 15 | 0.149 | 24 ± 15 | 17 ± 15 | 0.104 |
Antibiotic treatment before VAT | 18 (81) | 29 (80) | >0.999 | 15 (83) | 23 (88) | 0.676 |
Antibiotic treatment during the 8 days following random assignment | 22 (100) | 21 (58) | <0.001 | 18 (100) | 10 (38) | <0.001 |
Reasons for antibiotic treatment during the 8 days following random assignment | ||||||
VAT | 22 (100) | 0 (0) | <0.001 | 18 (100) | 0 (0) | <0.001 |
VAP | 0 (0) | 15 (41) | <0.001 | 0 (0) | 10 (38) | 0.003 |
Other infections | 0 (0) | 6 (16) | 0.073 | 0 (0) | 0 (0) | NA |
Antibiotic treatment after day 8 post-random assignment | 6 (27) | 8 (22) | 0.756 | 3 (16) | 5 (19) | >0.999 |