Antimicrobial treatment for ventilator-associated tracheobronchitis: a randomized, controlled, multicenter study

Table 2 Patient characteristics at the day of random assignment

	Intention to treat			Modified intention to treat
	Antibiotic treatment n = 22	No antibiotic treatment n = 36	P value	Antibiotic treatment n = 18	No antibiotic treatment n = 26	P value
Duration of mechanical ventilation before random assignment, days	17 ± 9	13 ± 6	0.232	17 ± 10	12 ± 6	0.113
SAPS II	33 ± 13	36 ± 13	0.195	32 ± 10	36 ± 12	0.120
LOD score	4.1 ± 2	4.9 ± 2.4	0.185	3.8 ± 1.5	4.8 ± 2.6	0.210
Temperature, °C	38.1 ± 0.6	38.3 ± 0.6	0.408	38.2 ± 0.5	38.2 ± 0.4	0.402
Leucocytes, × 10⁹ cells/L	12 ± 5.9	12 ± 6	0.619	11.2 ± 4.2	11.9 ± 5.7	0.775
C-reactive protein, mg/mL	111 ± 61	104 ± 80	0.417	104 ± 50	95 ± 67	0.295
Procalcitonin, ng/mL, median (IR)	0.6 (0.10–3.1)	0.8 (0.5–2.7)	0.282	0.7 (0.05–2.8)	0.83 (0.36–2.1)	0.494

Results of univariate analysis are presented. Data are expressed as mean ± standard deviation unless otherwise indicated. IR, interquartile range; LOD, logistic organ dysfunction; SAPS, Simplified Acute Physiology Score.

ISSN: 1364-8535