Table 2 Data relating to infusions of DrotAA
From: Drotrecogin alfa (activated): real-life use and outcomes for the UK
Infusion-related data | All admissions receiving DrotAA (n = 1,292) |
|---|---|
Time from unit admission to start of infusion (hours; median [IQR]) | 19.5 (9.3–35.3) |
Received complete 96-hour infusion (n [%]) | 896 (69.9) |
Reason for not receiving complete infusion (n [%]) | |
   Deterioration/treatment withdrawn/died | 195 (50.8) |
   Actual/possible bleeding | 91 (23.7) |
   Patient improved/left ward | 34 (8.9) |
   Other intervention/treatment outside unit | 16 (4.2) |
   Criteria reassessed/incorrect | 9 (2.3) |
   Timing error | 8 (2.1) |
   Other intervention/treatment in unit | 5 (1.3) |
   Macro/micro drug supply issues | 4 (1.0) |
   Infused over shorter time period | 1 (0.3) |
   No reason given/not known | 21 (5.5) |
Interruption in the infusion (n [%]) | 304 (24.0) |
Time from start of infusion to interruption (hours; median [IQR]) | 24.0 (13.2–49.0) |
Duration of interruption (hours; median [IQR]) | 5 (3–10) |
Reason for interruption (n [%]) | |
   Lines/catheters/cannula/drain/dressing-inserted/changed/removed/re-sited/fell out | 144 (48.0) |
   To theatre | 48 (16.0) |
   Bleeding related (actual/suspected) | 35 (11.7) |
   Intervention off unit | 15 (5.0) |
   Tracheostomy | 15 (5.0) |
   Intervention on unit | 11 (3.7) |
   In error | 10 (3.3) |
   Macro/micro drug supply issues | 10 (3.3) |
   Patients condition improved/left unit | 1 (0.3) |
   No reason given/not known | 11 (3.7) |