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Table 2 Data relating to infusions of DrotAA

From: Drotrecogin alfa (activated): real-life use and outcomes for the UK

Infusion-related data All admissions receiving DrotAA (n = 1,292)
Time from unit admission to start of infusion (hours; median [IQR]) 19.5 (9.3–35.3)
Received complete 96-hour infusion (n [%]) 896 (69.9)
Reason for not receiving complete infusion (n [%])
   Deterioration/treatment withdrawn/died 195 (50.8)
   Actual/possible bleeding 91 (23.7)
   Patient improved/left ward 34 (8.9)
   Other intervention/treatment outside unit 16 (4.2)
   Criteria reassessed/incorrect 9 (2.3)
   Timing error 8 (2.1)
   Other intervention/treatment in unit 5 (1.3)
   Macro/micro drug supply issues 4 (1.0)
   Infused over shorter time period 1 (0.3)
   No reason given/not known 21 (5.5)
Interruption in the infusion (n [%]) 304 (24.0)
Time from start of infusion to interruption (hours; median [IQR]) 24.0 (13.2–49.0)
Duration of interruption (hours; median [IQR]) 5 (3–10)
Reason for interruption (n [%])
   Lines/catheters/cannula/drain/dressing-inserted/changed/removed/re-sited/fell out 144 (48.0)
   To theatre 48 (16.0)
   Bleeding related (actual/suspected) 35 (11.7)
   Intervention off unit 15 (5.0)
   Tracheostomy 15 (5.0)
   Intervention on unit 11 (3.7)
   In error 10 (3.3)
   Macro/micro drug supply issues 10 (3.3)
   Patients condition improved/left unit 1 (0.3)
   No reason given/not known 11 (3.7)
  1. IQR, interquartile range.