Table 5 Studies comparing quantitative cultures to clinical diagnosis
From: Diagnosis of ventilator-associated pneumonia: a systematic review of the literature
First author | Sample | Dx tests | Gold standard | Results |
|---|---|---|---|---|
Camargo, 2004, ** [59] | Mixed ICU, 106 pts | TA (105 and 106) & TA (qualit) | Clinical (ad hoc) | • TA (106): sens = 26%, spec = 78%, PPV = 20%, NPV = 83% • TA (105): sens = 65%, spec = 48%, PPV = 21%, NPV = 87% • TA (qualit): sens = 81%, spec = 23%, PPV = 18%, NPV = 86% |
Mentec, 2004, ** [60] | Mixed ICU, 63 pts | TA (105), bPTC (103), PTC (103), BAL (104) | Clinical + Rx (ad hoc) | • For quantitative cultures: TA: sens = 82%, spec = 67%, ROC = 0,78; bPTC: sens = 62%, spec = 94%, ROC = 0,83; PTC: sens = 71%, spec = 94%, ROC = 0,85; BAL: sens = 94%, spec = 100%, ROC = 0.98 • For Gram stain: TA: sens = 94%, spec = 50%; bPTC: sens = 56%, spec = 94%; PTC sens = 65%, spec = 83%; BAL sens = 100%, spec = 94% |
Woske, 2001, ** [61] | Surgical ICU, 103 pts, consecutive | BAL (104) & PSB (103) & TA (105 and 106) | CPIS ≥6 | • BAL: sens = 90%. • PSB: sens = 83%. • TA (105): sens = 90%. • TA (106): sens = 50%. |
Meduri, 1992, ** [84] | Mixed ICU, 25 pts | pBAL (104) & PSB | Clinical | • pBAL: Spec = 100%, NPV = 100% |
Salata, 1987, ** [85] | Mixed ICU, 51 pts | TA | Clinical | • TA: higher Gram stain grading for neutrophils: p < 0.05 • TA: higher bacterial colony count: p < 0.05 |
Castro, 1991, ** [86] | Mixed ICU, 103 pts | PSB (103) | Clinical | • PSB: sens = 84%, spec = 67% |