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Table 3 Summary of main pharmacokinetic results

From: Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial

Tmax, hours

Cmax, pg/mL

AUC(0–24), ng-hours/L

Overall t1/2, hours

Oral clearance (Cl/F), L/hour

C(08), pg/mL

0.5 (0)

14,974 (3,200)

29,979 (8,205)

1.47 (0.28)

351.0 (96.7)

84 (64)

  1. Data are presented as mean (standard deviation). AUC(0–24), area under the concentration time curve between time 0 and 24 hours; C(08), plasma concentration at 8 a.m.; Cl/F, clearance/bioavailability (oral dose/area under the zero moment curve); Cmax, maximum plasma concentration; t1/2, plasma half-life; Tmax.
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Critical Care

ISSN: 1364-8535