Characteristic | Placebo (n = 12) | Melatonin (n = 12) |
---|---|---|
Male, number (percentage) | 7 (58.3) | 4 (33.3) |
Reason for ICU admission, number (percentage) | Â | Â |
   Severe sepsis | 8 (66.7) | 10 (83.3) |
   Postoperative respiratory failure | 2 (16.7) | 1 (8.3) |
   Pneumonia | 2 (16.7) | 1 (8.3) |
Age in years, mean (SD) | 58.7 (12.5) | 69.9 (12.0) |
APACHE II score on study entry, mean (SD) | 16.8 (3.4) | 17.3 (3.8) |
Actual body weight in kilograms, median (IQR) | 69.0 (57.4; 77.5) | 65.0 (63.5; 70.0) |
Ideal body weight in kilograms, mean (SD) | 60.0 (6.9) | 57.2 (6.5) |
Body mass index, mean (SD) | 24.6 (4.7) | 25.0 (3.1) |
Patients' usual sleep quantity in hoursa, mean (SD) | 6.5 (1.57) | 6.2 (2.07) |
ICU length of stay prior to study in days, median (IQR) | 16.5 (13.0; 20.5) | 16.5 (11.0; 19.0) |
Time of ventilation prior to study in days, mean (SD) | 20.0 (14.3) | 13.6 (6.5) |
Sedation (morphine/midazolam) prior to study, number (percentage) | 2 (16.7) | 2 (16.7) |
Time since sedation stopped prior to study in days, mean (SD) | 6.6 (2.9) | 7.5 (4.7) |
Delirium during study period, number (percentage) | 1 (8.3) | 4 (33.3) |
Ventilation mode on nights 3 and 4, number (percentage) | Â | Â |
   BiPAP/CPAP-ASB | 7 (70.0) | 7 (58.3) |
   External CPAP/Hi-flow oxygen | 3 (30.0) | 5 (41.7) |