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Table 4 Comparison of statistical significance for patient risk variables between survivors and non-survivors

From: Implementation and evaluation of the SPRINT protocol for tight glycaemic control in critically ill patients: a clinical practice change

  Survivors Non-survivors P value
SPRINT cohort n = 310 n = 61  
Average BG, mmol/L 6.1 (5.6–6.6) 5.9 (5.5–6.5) 0.55a
Maximum BG, mmol/L 9.9 (8.6–11.8) 10.4 (8.5–12.1) 0.62a
BG range, mmol/L 6.1 (4.7–8.1) 6.5 (5.0–8.8) 0.35a
APACHE II score 18.0 (14.0–22.0) 25.0 (18.0–30.3) <0.01a
APACHE II risk of death 23% (12%-41%) 50% (26%-71%) <0.01a
Average percentage goal feed 48% (0%-71%) 54% (29%-68%) 0.42a
Average hourly insulin, U/hour 2.7 (2.2–3.3) 2.5 (2.1–3.2) 0.65a
Diabetic history 56 (18.1%) 6 (9.8%) 0.12b
Retrospective cohort n = 336 n = 77  
Average BG, mmol/L 7.5 (6.6–8.4) 7.3 (6.6–8.3) 0.83a
Maximum BG, mmol/L 10.5 (9.4–12.6) 11.3 (10.0–13.6) 0.04a
BG range, mmol/L 5.8 (3.8–8.6) 6.8 (4.7–9.5) 0.05a
APACHE II score 18.0 (15.0–22.0) 24.0 (18.8–29.0) <0.01a
APACHE II risk of death 25% (13%-43%) 51% (23%-67%) <0.01a
Average hourly insulin, U/hour 0.8 (0.0–1.7) 1.0 (0.5–1.5) 0.33a
Diabetic history 58 (17.3%) 13 (16.9%) 0.94b
  1. Statistical significance was tested for average, maximum and range of blood glucose, APACHE II score, average feed rate, and diabetic history between SPRINT intensive care unit survivors and mortalities. Data are expressed as number (percentage) or per-patient median (interquartile range) where appropriate. aMann-Whitney U test; bchi-square test. APACHE, Acute Physiology And Chronic Health Evaluation; BG, blood glucose concentration; SPRINT, Specialised Relative Insulin Nutrition Tables.