Table 4 Day 4 (end of infusion) values in PROWESS:individual surrogate performance score (PTEE)
Day 4 measure | DrotAA patients (mean [SD]/median) | Placebo patients (mean [SD]/median) | P a | Individual surrogate performance score (PTEE)b |
|---|---|---|---|---|
Protein C (%) | 70.6 (36.2)/67.0 | 62.7 (36.9)/59.0 | <0.0001 | 57.2% |
Protein S (%) | 53.3 (29.0)/52.0 | 53.5 (30.2)/53.0 | 0.95 | -0.8%c |
Antithrombin III (%) | 70.3 (27.0)/69.5 | 69.0 (28.0)/70.0 | 0.38 | 13.4% |
Interleukin-6 (pg/ml) | 3,649 (30,280)/75.5 | 4948 (33379)/79.5 | 0.78 | 0.3%d |
Prothrombin time (seconds) | 18.6 (7.4)/16.7 | 18.5 (8.4)/16.2 | 0.0003 | -30.4%c, d |
D-dimer (μg/ml) | 4.63 (5.41)/3.12 | 7.13 (7.87)/4.61 | <0.0001 | 40.5%d |
Cardiovascular SOFA | 1.48 (1.60)/1.00 | 1.67 (1.64)/1.00 | 0.01 | 40.8% |
Respiratory SOFA | 2.25 (1.03)/2.00 | 2.30 (1.01)/2.00 | 0.25 | 12.7% |
Renal SOFA | 0.74 (1.12)/0.00 | 0.80 (1.17)/0.00 | 0.39 | 10.6% |
Hematologic SOFA | 0.89 (1.12)/0.00 | 0.92 (1.15)/0.00 | 0.79 | 5.1% |
Hepatic SOFA | 0.61 (0.92)/0.00 | 0.53 (0.89)/0.00 | 0.04 | -13.6% |