| | |
Sample size
|
Univariate odds ratio
|
|---|
|
Measure
|
Cut-offa
|
Higher risk
|
Lower risk
|
Odds ratio (95% CI)
|
P
|
|---|
|
Protein C (%)
|
<42
|
240
|
578
|
4.63 (3.35 to 6.41)
|
<0.0001
|
|
Protein S (%)
|
<42
|
297
|
521
|
3.25 (2.38 to 4.43)
|
<0.0001
|
|
Antithrombin III (%)
|
<60
|
306
|
512
|
4.17 (3.05 to 5.71)
|
<0.0001
|
|
Interleukin-6 (pg/ml)
|
≥185.6
|
264
|
563
|
7.27 (5.23 to 10.11)
|
<0.0001
|
|
Prothrombin time (seconds)
|
≥18.4
|
233
|
585
|
6.13 (4.40 to 8.56)
|
<0.0001
|
|
D-dimer (μg/ml)
|
≥4.63
|
408
|
410
|
2.13 (1.57 to 2.89)
|
<0.0001
|
|
Cardiovascular SOFA
|
≥3
|
301
|
539
|
7.32 (5.28 to 10.13)
|
<0.0001
|
|
Respiratory SOFA
|
≥3
|
358
|
482
|
3.36 (2.48 to 4.56)
|
<0.0001
|
|
Renal SOFA
|
≥1
|
335
|
505
|
4.82 (3.52 to 6.59)
|
<0.0001
|
|
Hematologic SOFA
|
≥2
|
252
|
588
|
3.42 (2.50 to 4.68)
|
<0.0001
|
|
Hepatic SOFA
|
≥1
|
256
|
573
|
2.11 (1.55 to 2.89)
|
<0.0001
|
- aCut-off was defined by the day 4 (end of infusion) value that resulted in maximum sensitivity and specificity for predicting 28-day mortality. CI, confidence interal; PROWESS, Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis; SOFA, Sequential Organ Failure Assessment.
