PC and d-dimer levels. Shown are the mean ± standard error (a) protein C (PC) and (b) d-dimer levels based on time of death. Raw values with no imputation were included. PROWESS (Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis) drotrecogin alfa (activated; DrotAA) patients with baseline measures were classified according to timing of death (n = PC/d-dimer): death ≤ 5 days after start of infusion (n = 79/86); death after 6 to 15 days (n = 81/84); and survival to day 28 and hospital discharge (n = 544/577). The PC data were reported by Vangerow and coworkers  and comparable PC data for PROWESS placebo patients were reported by Macias and Nelson .