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Table 1 Effect of extended infusion of carbapenem antibiotics

From: Pharmacodynamic optimization of β-lactams in the patient care setting

 

Bactericidal cumulative reaction of response (%)a

 

Antibiotic regimen

30-minute infusion

3-hour infusion

Change (%)

Imipenem 1 g q8h

69.3

72.0

+2.7

Meropenem 1 g q8h

77.1

83.8

+6.7

Meropenem 2 g q8h

84.1

88.1

+4.0

  1. Shown is the effect of extended infusion of carbapenem antibiotics on the bactericidal cumulative fraction of response against multidrug-resistant Pseudomonas aeruginosa [17]. aBactericidal exposure defined as 40% time above minimum inhibitory concentration. q8h, every 8 hours.