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Table 1 Clinical characteristics of enrolled patients

From: Detecting myocardial infarction in critical illness using screening troponin measurements and ECG recordings

  Total MI Elevated cTn only No cTn elevation p value3 p value4
  (N = 103) (N = 37) (N = 15) (N = 51)   
Age, mean (SD) 64.1 ± 17.5 69.9 ± 14.9 64.3 ± 21.8 59.7 ± 16.9 0.018 - MI vs cTn, p = 0.467
- cTn vs no cTn elevation, p = 0.309
- MI vs no cTn elevation, p = 0.004
Female sex, N (%) 44 (42.7) 16 (43.2) 4 (26.7) 24 (47.1) 0.372 - MI vs cTn, p = 0.352
- cTn vs no cTn elevation, p = 0.236
- MI vs no cTn elevation, p = 0.829
APACHE II score, mean (SD) 21.4 ± 10.3 28.2 ± 9.5 22 ± 8.3 16.2 ± 8.3 <0.0001 - MI vs cTn, p = 0.045
- cTn vs no cTn elevation, p = 0.014
- MI vs no cTn elevation p < 0.0001
Medical, N (%) 65 (63) 32 (86.5) 10 (66.7) 23 (45.1) <0.0001 - MI vs cTn, p = 0.129
- cTn vs no cTn Elevation p = 0.240
- MI vs no cTn elevation p < 0.0001
Past medical history, N (%)       
Smoking 28 (27.2) 10 (27.0) 4 (26.7) 14 (27.5) 0.998 - MI vs cTn, p = 1.000
- cTn vs no cTn elevation, p = 1.000
- MI vs no cTn elevation, p = 1.000
Hypertension 54 (52.4) 24 (64.9) 9 (60.0) 21 (41.2) 0.073 - MI vs cTn, p = 0.760
- cTn vs no cTn elevation, p = 0.245
- MI vs no cTn elevation, p = 0.033
Diabetes mellitus1 25 (24.3) 13 (35.1) 4 (26.7) 8 (15.7) 0.107 - MI vs cTn, p = 0.747
- cTn vs no cTn elevation, p = 0.446
- MI vs no cTn elevation, p = 0.044
Hyperlipidemia 17 (16.5) 6 (16.2) 5 (33.3) 6 (11.8) 0.141 - MI vs cTn, p = 0.260
- cTn vs no cTn elevation, p = 0.107
- MI vs no cTn elevation, p = 0.549
Documented coronary disease/angina 3 (2.9) 1 (2.7) 1 (6.7) 1 (2.0) 0.632 - MI vs cTn, p = 0.498
- cTn vs no cTn elevation, p = 0.406
- MI vs no cTn elevation, p = 1.000
Prior myocardial infarction 5 (4.9) 4 (10.8) 1 (6.7) 0 (0) 0.062 - MI vs cTn, p = 1.000
- cTn vs no cTn elevation, p = 0.227
- MI vs no cTn elevation, p = 0.028
Congestive heart failure 16 (15.5) 10 (27) 2 (13.3) 4 (7.8) 0.048 - MI vs cTn, p = 0.470
- cTn vs no cTn elevation, p = 0.612
- MI vs no cTn elevation, p = 0.020
Peripheral vascular disease 13 (12.6) 7 (18.9) 3 (20.0) 3 (5.9) 0.124 - MI vs cTn, p = 1.000
- cTn vs no cTn elevation, p = 0.125
- MI vs no cTn elevation, p = 0.088
Stroke/transient ischemic attack 10 (9.7) 5 (13.5) 3 (20.0) 2 (3.9) 0.112 - MI vs cTn, p = 0.676
- cTn vs no cTn elevation, p = 0.073
- MI vs no cTn elevation, p = 0.126
Baseline life support interventions, N (%)       
Ventilation       
Invasive mechanical ventilation 59 (57.3) 27 (73.0) 7 (46.7) 25 (49.0) 0.054 - MI vs cTn, p = 0.108
- cTn vs no cTn elevation, p = 0.100
- MI vs no cTn elevation, p = 0.029
Non-invasive mechanical ventilation 4 (3.9) 1 (2.7) 1 (6.7) 2 (3.9) 0.799 - MI vs cTn, p = 0.498
- cTn vs no cTn elevation, p = 0.545
- MI vs no cTn elevation, p = 1.000
Inotropes and vasopressors, N (%)       
Epinephrine 3 (2.9) 3 (8.1) 0 (0) 0 (0) 0.064 - MI vs cTn, p = 0.548
- cTn vs no cTn elevation, p = NE
- MI vs no cTn elevation, p = 0.071
Dopamine2 6 (5.8) 5 (13.5) 0 (0) 1 (2.0) 0.043 - MI vs cTn, p = 0.305
- cTn vs no cTn elevation, p = 1.000
- MI vs no cTn elevation, p = 0.079
Norepinephrine 14 (13.6) 9 (24.3) 2 (13.3) 3 (5.9) 0.045 - MI vs cTn, p = 0.477
- cTn vs no cTn elevation, p = 0.318
- MI vs no cTn elevation, p = 0.024
Dobutamine 2 (1.9) 2 (5.4) 0 (0) 0 (0) 0.162 - MI vs cTn, p = 1.000
- cTn vs no cTn elevation, p = NE
- MI vs no cTn elevation, p = 0.174
Phenylephrine 3 (2.9) 3 (8.1) 0 (0) 0 (0) 0.064 - MI vs cTn, p = 0.548
- cTn vs no cTn elevation, p = NE
- MI vs no cTn elevation, p = 0.071
Vasopressin 1 (1.0) 1 (2.7) 0 (0) 0 (0) 0.406 - MI vs cTn, p = 1.000
- cTn vs no cTn elevation, p = NE
- MI vs no cTn elevation, p = 0.420
Hemodialysis, N (%)       
Intermittent dialysis 9 (8.7) 6 (16.2) 1 (6.7) 2 (3.9) 0.125 - MI vs cTn, p = 0.658
- cTn vs no cTn elevation, p = 0.545
- MI vs no cTn elevation, p = 0.065
Continuous renal replacement therapy 1 (1.0) 1 (2.7) 0 (0) 0 (0) 0.406 - MI vs cTn, p = 1.000
- cTn vs no cTn elevation, p = NE
- MI vs no cTn elevation, p = 0.420
  1. APACHE = Acute Physiology and Chronic Health Evaluation; cTn = cardiac troponin; MI = myocardial infarction; NE = not estimable; 1Managed with oral agents and/or insulin; 2>3 μg/kg/min; 3p value indicates a 3-way comparison; 4p value indicates a 2-way comparison.