Table 2 Baseline and Dobutamine-Stressed Hemodynamic/Cardiovascular and Metabolic Variables
From: Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock
| Â | Survivor Baseline (n = 8) | Non-survivors Baseline (n = 15) | P value: survivor vs non-survivor-baseline | Survivor: change from baseline | Non-survivor: change from baseline | P value: survivor vs non-survivor-change from baseline |
|---|---|---|---|---|---|---|
HR (min-1) | 88.3 ± 5.1 | 106.7 ± 5.7 | .0254 | 16.1 ± 4.7 | 14.9 ± 4.2 | .8645 |
sBP (mmHg) | 124.3 ± 6.8 | 114.0 ± 4.9 | .2427 | 24.6 ± 12.6 | 8.3 ± 5.2 | .1630 |
dBP (mmHg) | 64.1 ± 4.2 | 57.6 ± 2.8 | .2207 | -1.6 ± 3.2 | 2.3 ± 2.4 | .3508 |
PP (mmHg) | 60.1 ± 6.5 | 56.4 ± 4.7 | .6541 | 26.3 ± 10.4 | 5.9 ± 4.1 | .0403 |
MP (mmHg) | 84.2 ± 4.2 | 76.4 ± 2.8 | .1391 | 7.1 ± 6.0 | 4.3 ± 3.0 | .6225 |
SVI (ml/beat/m2) | 31.5 ± 3.0 | 29.0 ± 3.0 | .5663 | 16.4 ± 3.7 | 3.0 ± 1.0 | .0003 |
CI (L/min/m2) | 2.78 ± 0.32 | 3.01 ± 0.33 | .5910 | 2.24 ± 0.55 | 0.80 ± 0.22 | .0093 |
RAP (mmHg) | 13.6 ± 1.9 | 14.5 ± 1.4 | .7346 | -0.8 ± 0.9 | 0.4 ± 0.8 | .9405 |
sPAP (mmHg) | 44.6 ± 4.6 | 40.5 ± 2.2 | .4459 | 3.5 ± 5.1 | 2.2 ± 2.1 | .6389 |
dPAP (mmHg) | 22.6 ± 2.9 | 19.5 ± 0.8 | .3253 | -5.1 ± 1.8 | 0.6 ± 1.1 | .0133 |
PAM (mmHg) | 30.0 ± 3.3 | 26.5 ± 0.9 | .3494 | -2.3 ± 2.5 | 1.1 ± 1.2 | .2442 |
PWP (mmHg) | 19.8 ± 2.8 | 17.6 ± 1.1 | .4896 | -1.8 ± 1.4 | -1.1 ± 0.8 | .5829 |
PAO2 (mmHg) | 95.6 ± 12.2 | 97.5 ± 9.4 | .9034 | -2.3 ± 8.2 | -12.2 ± 9.2 | .4518 |
PACO2 (mmHg) | 35.6 ± 1.5 | 32.0 ± 2.3 | .2000 | -1.4 ± 0.9 | -0.3 ± 0.8 | .3846 |
O2sat (%) | 95.2 ± 1.2 | 96.0 ± 0.7 | .4750 | -0.6 ± 1.2 | -1.0 ± 0.7 | .6463 |
MVO2 (% | 62.3 ± 3.7 | 62.1 ± 2.8 | .9879 | 8.8 ± 2.0 | 2.0 ± 1.6 | .0234 |
LVEF (%) | 50 ± 5 | 57 ± 4 | .3184 | 11.8 ± 3.8 | 1 ± 2 | .0160 |
LVEDVI (mLm2) | 65.2 ± 6.5 | 52.7 ± 5.8 | .1691 | 19.9 ± 7.4 | 7.8 ± 5.4 | .1987 |
LVESVI (mL/m2) | 33.6 ± 6.7 | 23.0 ± 4.4 | .2535 | 3.5 ± 6.5 | 5.1 ± 5.0 | .8497 |
LVSWI (g.m/m2) | 28.3 ± 4.1 | 22.9 ± 2.3 | .2567 | 22.3 ± 7.1 | 5.2 ± 1.4 | .0054 |
SVRI (dynes/sec/cm2/m2) | 2232 ± 314 | 1835 ± 170 | .2728 | -901 ± 246 | -162 ± 150 | .0154 |
RVEF (%) | 65 ± 3 | 64 ± 4 | .8489 | 4.8 ± 4.1 | 2.9 ± 2.5 | .6793 |
RVEDVI (mL/m2) | 48.4 ± 4.2 | 46.1 ± 4.7 | .7194 | 25.2 ± 8.8 | 1.7 ± 2.6 | .0047 |
RVESVI (mL/m2) | 16.8 ± 2.6 | 17.4 ± 3.0 | .8874 | 8.7 ± 6.7 | -1.0 ± 2.4 | .1125 |
RVSWI (g.m/m2) | 6.8 ± 1.1 | 4.5 ± 0.6 | .0916 | 1.8 ± 0.7 | 1.4 ± 0.6 | .4365 |
PVRI (dynes/sec/cm2/m2) | 322 ± 50 | 263 ± 45 | .3910 | -147 ± 39 | -21.0 ± 32 | .0390 |
CaO2 (mL/dL) | 13.4 ± 1.0 | 12.8 ± 0.5 | .6190 | -0.1 ± 0.2 | -0.1 ± 0.1 | .8551 |
CvO2 (mL/dL) | 8.6 ± 0.6 | 8.4 ± 0.6 | .8161 | 1.3 ± 0.4 | 0.3 ± 0.2 | .0208 |
DO2I (mL/min/m2) | 352 ± 24 | 383 ± 45 | .5448 | 301 ± 78 | 98 ± 29 | .0084 |
VO2I (mL/min/m2) | 122 ± 10 | 122 ± 6 | .9967 | 32 ± 10 | 22 ± 7 | .3652 |
sbp/lvesvi (mm Hg/mL/m2) | 4.57 ± 0.73 | 7.33 ± 1.51 | .1152 | 3.12 ± 1.32 | 0.15 ± 0.5 | .0188 |
PAS/rvesvi (mm Hg/mL/m2) | 3.06 ± 0.44 | 3.21 ± 0.51 | .8255 | 0.69 ± 0.69 | 0.71 ± 0.90 | .9877 |
lvedvi/pwp (mL/m2/mmHg) | 3.82 ± 0.67 | 3.18 ± 0.38 | .4123 | 1.52 ± 0.47 | 0.74 ± 0.35 | .1964 |
RVEDVI/RAP (mL/m2/mmHg) | 4.24 ± 0.89 | 3.44 ± 0.40 | .4288 | 3.63 ± 2.34 | 0.23 ± 0.46 | .0783 |
pH | 7.38 ± 0.3 | 7.41 ± 0.02 | .3988 | 0 ± 0.01 | 0 ± 0.01 | .8820 |
Qs/QT | 0.11 ± 0.02 | 0.11 ± 0.02 | .8990 | 0.07 ± 0.05 | 0.03 ± 0.02 | .4793 |
OER | 0.35 ± 0.03 | 0.35 ± 0.03 | .9928 | -0.1 ± 0.03 | -0.03 ± 0.01 | .0160 |