|
Cardiac surgery
| | | | |
|
Boldt et al., 1986 [37]
|
55
|
Coronary artery bypass grafting
|
300 ml 20% albumin intraoperatively after bypass vs 500 ml 3% HES 200/0.5 vs 500 ml 3.5% gelatin vs no additional volume
|
Post-bypass COP rebound greater in albumin than other groups (p < 0.05)
|
|
Boldt et al., 1993 [41]
|
30
|
Cardiac defect repair in children < 3 years old
|
20% albumin vs 6% HES 200/0.5 to stabilize hemodynamics before bypass
|
On-bypass urine output in HES group lower by 57% than that of albumin group (p < 0.05)
|
|
Magder and Lagonidis, 1999 [52]
|
28
|
Stable patients after cardiac bypass surgery
|
100 ml 25% albumin vs saline to increase right atrial pressure by 2 mm Hg
|
Greater increase in cardiac output among hyperoncotic albumin recipients, suggesting an inotropic effect
|
|
Non-cardiac surgery
| | | | |
|
Zetterström and Hedstrand, 1981 [36]
|
30
|
Elective major abdominal surgery
|
300–400 ml 20% albumin on operation day, 200 ml on next day and 100 ml/day for subsequent 3 days vs no albumin
|
In albumin recipients COP significantly closer to preoperative level on postoperative days 2–6
|
|
Prien et al., 1990 [39]
|
18
|
Abdominal surgery
|
20% albumin vs 10% HES 200/0.5 vs Ringer's lactate to maintain preoperative CVP
|
Significantly lower intraoperative intestinal edema after albumin compared with either HES or Ringer's lactate; impaired coagulation in HES recipients
|
|
Trauma
| | | | |
|
Boldt et al., 1995 [44]
|
30
|
Trauma of ISS > 15
|
20% albumin vs 10% HES 200/0.5 to 12–16 mm Hg target CVP, PCWP or both
|
No between-group differences in daily profiles of plasma thrombomodulin, proteins C and S and thrombin-antithrombin III
|
|
Boldt et al., 1996 [45]
|
30
|
Trauma of ISS between 15 and 30
|
20% albumin vs 10% HES 200/0.5 to 12–18 mm Hg target PCWP
|
HES 200/0.5 but not albumin increased cardiac index, PaO2/FiO2, DO2I and VO2I (p < 0.05 for all comparisons)
|
|
Boldt et al., 1996 [46]
|
28
|
Trauma of ISS > 15
|
20% albumin vs 10% HES 200/0.5 to 12–16 mm Hg target CVP, PCWP or both
|
Maximum platelet aggregation declined in both groups (p < 0.05)
|
|
Boldt et al., 1996 [48]
|
28
|
Trauma of ISS > 15
|
20% albumin vs 10% HES 200/0.5 to 10–15 mm Hg target PCWP
|
Vasopressin decreased in HES 200/0.5 but not albumin group (p < 0.05)
|
|
Boldt et al., 1998 [49]
|
150
|
Trauma of ISS > 15
|
20% albumin vs 10% HES 200/0.5 to 12–15 mm Hg target PCWP
|
PaO2/FiO2 increased by HES 200/0.5 but not albumin (p < 0.05); higher cardiac index, DO2I and VO2I in HES 200/0.5 group (p < 0.05 for all comparisons); no differences in incidence of renal failure, platelet count, PT or aPTT
|
