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Table 3 Risk factors for major bleeding

From: Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors

Putative risk factor

Univariate analysis

Multivariable analysis

 

Hazard ratio (95% confidence interval)

P value

Hazard ratio (95% confidence interval)

P value

Baseline factors

    

   Age (10-year increase)

0.82 (0.58 to 1.15)

0.25

-

-

   Acute Physiology and Chronic Health Evaluation II score (10-point increase)

0.97 (0.49 to 1.93)

0.93

-

-

   Surgical patient

1.76 (0.50 to 6.26)

0.38

-

-

   Baseline renal disease classification (with reference to acute renal failure)

    

Acute on chronic

0.92 (0.18 to 4.56)

0.91

  

Chronic renal failurea

-

-

  

Chronic hemodialysis

3.59 (0.71 to 18.15)

0.12

  

Time-dependent factors

    

   Exposure to continuous hemodialysisb

2.17 (0.55 to 8.51)

0.27

-

-

   Exposure to intermittent hemodialysisb

1.25 (0.32 to 4.85)

0.75

-

-

   Exposure to therapeutic-dose unfractionated heparinb

2.87 (0.59 to 13.97)

0.19

-

-

   Exposure to prophylactic-dose unfractionated heparinb

1.10 (0.14 to 8.80)

0.93

-

-

   Exposure to acetylsalicylic acidb

3.62 (0.93 to 14.11)

0.06

6.30 (1.35 to 29.35)

0.02

   Detectable trough anti-activated factor X level (≥ 0.01 IU/ml)

0.76 (0.15 to 3.81)

0.74

-

-

   International Normalized Ratio (0.5-unit increase)

1.44 (0.95 to 2.17)

0.09

1.68 (1.07 to 2.66)

0.03

   Partial thromboplastin time (10-unit increase)

1.13 (0.99 to 1.29)

0.06

-

-

   Platelet count (50-unit decrease)

1.19 (0.94 to 1.51)

0.16

-

-

  1. aNo patient with major bleeding had this putative risk factor. bWithin 3 days prior to study enrollment.