Skip to main content

Table 2 Risk factors for deep vein thrombosis

From: Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors

Putative risk factor

Univariate analysis

Multivariable analysis

 

Hazard ratio (95% confidence interval)

P value

Hazard ratio (95% confidence interval)

P value

Baseline factors

    

   Age (10-year increase)

0.98 (0.64 to 1.50)

0.91

-

-

   Acute Physiology and Chronic Health Evaluation II score (10-point increase)

2.25 (1.03 to 4.91)

0.04

2.25 (1.03 to 4.91)

0.04

   Surgical patient

1.96 (0.44 to 8.81)

0.38

-

-

   Baseline renal disease classification (with reference to acute renal failure)

    

Acute on chronic

1.10 (0.21 to 5.78)

0.91

  

Chronic renal failurea

-

-

  

Chronic hemodialysisa

-

-

  

   Personal or family history of venous thromboembolisma

-

-

-

-

   Known thrombophilic disorder

6.48 (0.73 to 57.88)

0.09

-

-

   Malignancy (current or in past 5 years)a

-

-

-

-

Time-dependent factors

    

   Exposure to continuous hemodialysisb

1.56 (0.30 to 8.08)

0.59

-

-

   Exposure to intermittent hemodialysisb

1.09 (0.21 to 5.67)

0.92

-

-

   Exposure to therapeutic-dose unfractionated heparinb

-

-

-

-

   Exposure to prophylactic-dose unfractionated heparinb

0.99 (0.12 to 8.37)

0.99

-

-

   Exposure to acetylsalicylic acidb

0.58 (0.11 to 2.97)

0.51

-

-

   International Normalized Ratio (0.5-unit increase)

1.54 (1.05 to 2.24)

0.03

-

-

   Partial thromboplastin time (10-unit increase)

1.08 (0.78 to 1.49)

0.67

-

-

   Platelet count (50-unit decrease)

1.09 (0.85 to 1.39)

0.49

-

-

   Red blood cell transfusiona

1.27 (0.28 to 5.71)

0.75

-

-

   Fresh frozen plasma transfusiona,b

-

-

-

-

   Platelet transfusiona,b

-

-

-

-

   Central venous catheter placementb

-

-

-

-

   Exposure to inotropes/vasopressorsb

0.80 (0.15 to 4.15)

0.79

-

-

   Exposure to mechanical ventilationb

-

-

-

-

   Peak anti-FXa levels (most recent measurement prior to DVT diagnosis)c

0.04 (0.0 to 97.4)

0.43

-

-

  1. aNo patient with deep venous thrombosis (DVT) had this putative risk factor. bWithin 3 days prior to study enrollment. cThree out of seven patients with DVT did not have a peak anti-activated factor X (anti-FXa) level measured on the day of diagnosis of DVT; for this reason, the peak anti-FXa level was not included in the multivariable analysis.