Putative risk factor | Univariate analysis | Multivariable analysis | ||
---|---|---|---|---|
 | Hazard ratio (95% confidence interval) | P value | Hazard ratio (95% confidence interval) | P value |
Baseline factors | Â | Â | Â | Â |
   Age (10-year increase) | 0.98 (0.64 to 1.50) | 0.91 | - | - |
   Acute Physiology and Chronic Health Evaluation II score (10-point increase) | 2.25 (1.03 to 4.91) | 0.04 | 2.25 (1.03 to 4.91) | 0.04 |
   Surgical patient | 1.96 (0.44 to 8.81) | 0.38 | - | - |
   Baseline renal disease classification (with reference to acute renal failure) |  |  |  |  |
Acute on chronic | 1.10 (0.21 to 5.78) | 0.91 | Â | Â |
Chronic renal failurea | - | - | Â | Â |
Chronic hemodialysisa | - | - | Â | Â |
   Personal or family history of venous thromboembolisma | - | - | - | - |
   Known thrombophilic disorder | 6.48 (0.73 to 57.88) | 0.09 | - | - |
   Malignancy (current or in past 5 years)a | - | - | - | - |
Time-dependent factors | Â | Â | Â | Â |
   Exposure to continuous hemodialysisb | 1.56 (0.30 to 8.08) | 0.59 | - | - |
   Exposure to intermittent hemodialysisb | 1.09 (0.21 to 5.67) | 0.92 | - | - |
   Exposure to therapeutic-dose unfractionated heparinb | - | - | - | - |
   Exposure to prophylactic-dose unfractionated heparinb | 0.99 (0.12 to 8.37) | 0.99 | - | - |
   Exposure to acetylsalicylic acidb | 0.58 (0.11 to 2.97) | 0.51 | - | - |
   International Normalized Ratio (0.5-unit increase) | 1.54 (1.05 to 2.24) | 0.03 | - | - |
   Partial thromboplastin time (10-unit increase) | 1.08 (0.78 to 1.49) | 0.67 | - | - |
   Platelet count (50-unit decrease) | 1.09 (0.85 to 1.39) | 0.49 | - | - |
   Red blood cell transfusiona | 1.27 (0.28 to 5.71) | 0.75 | - | - |
   Fresh frozen plasma transfusiona,b | - | - | - | - |
   Platelet transfusiona,b | - | - | - | - |
   Central venous catheter placementb | - | - | - | - |
   Exposure to inotropes/vasopressorsb | 0.80 (0.15 to 4.15) | 0.79 | - | - |
   Exposure to mechanical ventilationb | - | - | - | - |
   Peak anti-FXa levels (most recent measurement prior to DVT diagnosis)c | 0.04 (0.0 to 97.4) | 0.43 | - | - |