Intensive insulin therapy and mortality in critically ill patients

Table 4 Multivariable regression analysis (maximum likelihood estimation): intensive care unit and hospital mortality^a

	Period II (n = 3,322)^b 1 Mar 02 to 30 Jun 03		Period III (n = 4,786)^b 1 Jul 03 to 28 Feb 05
	OR (95% CI)	P value	OR (95% CI)	P value
Entire ICU population
	n = 3,310		n = 4,739
ICU mortality	1.20 (0.98, 1.47)	0.071	1.26 (1.04, 1.53)	0.019
Hospital mortality	1.11 (0.93, 1.31)	0.248	1.15 (0.98, 1.35)	0.088
Entire ICU population, ICU LOS ≤ 3 days
	n = 1,808		n = 2,619
ICU mortality	1.21 (0.84, 1.74)	0.317	1.65 (1.16, 2.33)	0.005
Hospital mortality	1.17 (0.87, 1.57)	0.288	1.47 (1.11, 1.93)	0.007
Entire ICU population, ICU LOS >3 days
	n = 1,484		n = 2,033
ICU mortality	1.21 (0.95, 1.54)	0.125	1.14 (0.90, 1.44)	0.268
Hospital mortality	1.08 (0.87, 1.33)	0.501	1.01 (0.83, 1.24)	0.918

^aAll estimates are adjusted for admission age, history of diabetes, Simplified Acute Physiology Score (SAPS) II with age points removed, mechanical ventilation at ICU admission, and admitting service. ^bPeriod I is used as reference category for all analyses (n = 2,366 for the entire ICU population, n = 1,282 for patients in ICU ≤3 days, and n = 1,067 for patients in ICU >3 days). CI, confidence interval; ICU, intensive care unit; LOS, length of stay; OR, odds ratio.

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