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Table 3 Crude estimates of mortality, length of stay, and organ dysfunction stratified by study period

From: Intensive insulin therapy and mortality in critically ill patients

 

Period I

(n = 2,366)

1 Mar 01 to 28 Feb 02

Period II

(n = 3,322)

1 Mar 02 to 30 Jun 03

Period III

(n = 4,786)

1 Jul 03 to 28 Feb 05

P valuea

ICU mortality, n (%)

214 (9.04)

358 (10.78)

465 (9.75)

0.086

OR (95% CI) of ICU mortality

1.00

1.21 (1.01, 1.46)

1.09 (0.92, 1.29)

 

Hospital mortality, n (%)

334 (14.12)

522 (15.71)

686 (14.39)

0.157

OR (95% CI) of hospital mortality

1.00

1.13 (0.97, 1.32)

1.02 (0.88, 1.17)

 

Patients in ICU <3 days

n = 1,296

n = 1,829

n = 2,678

 

ICU mortality in patients in ICU <3 days, n (%)

76 (5.86)

128 (7.0)

181 (6.76)

0.428

Hospital mortality in patients in ICU <3 days, n (%)

122/1,174 (9.4)

203/1,829 (11.1)

283/2,678 (10.6)

0.310

Hospital mortality in patients with hypoglycemia <40 mg/dL, n (%)

9/24 (38)

23/53 (43)

41/103 (40)

0.863

Average SOFA score, mean ± SDb

1.65 (2.00)

1.77 (2.09)

1.62 (1.98)

<0.01

Maximum SOFA score, mean ± SDb

2.82 (2.85)

2.96 (2.99)

2.74 (2.84)

0.004

  1. aAnalysis of variance or chi-square comparing the three study periods; period I is used as reference. bScores for the Sequential Organ Failure Assessment (SOFA) can range from 0 to 24, with higher scores indicating a higher risk of death. CI, confidence interval; ICU, intensive care unit; OR, odds ratio; SD, standard deviation.