From: Intensive insulin therapy and mortality in critically ill patients
 | Period I (n = 2,366) 1 Mar 01 to 28 Feb 02 | Period II (n = 3,322) 1 Mar 02 to 30 Jun 03 | Period III (n = 4,786) 1 Jul 03 to 28 Feb 05 | P valuea |
---|---|---|---|---|
Patients receiving insulin infusion, n (%) | 206 (8.71) | 817 (24.59) | 2,027 (42.51) | <0.01 |
Patients receiving subcutaneous insulin, n (%) | 307 (14.21) | 349 (13.93) | 237 (8.65)c | <0.01 |
Patients receiving any insulin, n (%) | 513 (21.68) | 1,166 (35.10)b | 2,264 (47.48)c | <0.01 |
Average daily dose of insulin, units/24 hours, mean ± SDd | 72.4 (84.9) | 55.7 (58.7) | 47.5 (43.1) | <0.01 |
Central lab 6 a.m. blood glucose | n = 2,339 | n = 3,278 | n = 4,643 | Â |
   Mean ± SD | 144.0 ± 38.1 | 138.7 ± 34.4 | 129.3 ± 30.3 | <0.01 |
   Median (IQR) | 138 (120–160) | 134 (117–153) | 125 (112–140) |  |
Average daily blood glucose, mean ± SD | 146.6 ± 41.5 | 142.0 ± 37.4 | 132.6 ± 30.8 | <0.01 |
Average daily blood glucose, median (IQR) | 139 (121–161) | 136 (120–156) | 128 (115–143) |  |
Average point-of-care blood glucose | n = 700 | n = 1,407 | n = 2,610 | Â |
   Mean ± SD | 167.4 ± 46.7 | 148.0 ± 36.8 | 131.6 ± 31.2 | <0.01 |
Hypoglycemia <40 mg/dL, n (%)e | 24 (1.01) | 53 (1.60) | 103 (2.15)c | <0.01 |
Hypoglycemia <65 mg/dL, n (%)e | 115 (4.86) | 351 (10.57) | 810 (16.99) | <0.01 |
High-concentration glucose replacement, n (%)f | 86 (3.63) | 244 (7.34) | 462 (9.69) | <0.01 |
Hyperglycemia >200 mg/dL, n (%) | 330 (14.1) | 367 (11.1) | 339 (7.26) | <0.01 |