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Figure 5 | Critical Care

Figure 5

From: Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo

Figure 5

Effects of Rho kinase inhibition on severity of high tidal volume (HTV)-induced lung injury. Mice received a single dose of Rho kinase inhibitor Y27632 (10 mg/kg, intraperitoneal) or TRAP-6 (3 × 10-7 mol/mouse, intravenous) followed by mechanical ventilation (30 mL/kg, 4 hours) with or without OxPAPC injection (1.5 mg/kg, intravenous). Inhibition of the Rho pathway markedly attenuated HTV-induced bronchoalveolar lavage (BAL) cell count and protein content (a,b). TRAP-6 further enhanced HTV-induced increases in BAL cell count and protein content (c,d), whereas OxPAPC significantly reduced these effects. *p < 0.05 (n = 4 to 8 per group). Con, control; OxPAPC, oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine; TRAP-6, thrombin receptor activating peptide-6; Yinh, Y27632.

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