Figure 2
From: Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo
Effects of OxPAPC and DMPC on inflammatory cell recruitment in bronchoalveolar lavage (BAL) fluid of mice exposed to high tidal volume (HTV). HTV (30 mL/kg, 4 hours) induced a dramatic increase in BAL total cell count (a) and protein content (b), which was markedly attenuated by intravenous injection of OxPAPC (1.5 mg/kg) but not DMPC (1.5 mg/kg). There were no significant differences in cell counts and protein content between animals treated with vehicle, OxPAPC, or DMPC alone. *p < 0.05 (n = 6 to 9 per group). Con, control; DMPC, di-myristoyl-sn-glycero-3-phosphorylcholine; ND, no difference; OxPAPC, oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine.