Figure 1
From: Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo
Effects of OxPAPC on inflammatory cell recruitment in bronchoalveolar lavage (BAL) fluid of rats exposed to high tidal volume (HTV). HTV (20 mL/kg, 2 hours) induced a marked increase in BAL total cell count (a) and macrophages and neutrophils (b) compared with low tidal volume (LTV) controls. Intravenous OxPAPC (1.5 mg/kg) markedly attenuated this response, reducing inflammatory cells to control levels and significantly reducing neutrophil influx. *p < 0.05 versus LTV, **p < 0.05 versus HTV (n = 5 to 6 per group). (c) BAL protein concentration was assessed as a measure of vascular barrier disruption following 2 hours of mechanical ventilation with LTV or HTV. Intravenous OxPAPC (1.5 mg/kg) significantly reduced the pronounced increase in BAL protein induced by HTV mechanical ventilation (*p < 0.01 versus LTV, **p < 0.05 versus HTV). ND, no difference; OxPAPC, oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine; PMN, polymorphonuclear leukocyte.