Evolution of the glycemic penalty index (GPI) as a function of duration of algorithm application. The evolution of the GPI values as a function of duration of algorithm application (D) for the patients of group 1 who stayed for at least 100 h in the intensive care unit (ICU). Each line represents a patient. For example, the first star represents the GPI value that is calculated based on the blood glucose (BG) observations of the first 24 h of that specific patient. The second star gives the GPI value based on the measured BG signal of the first 48 h; the third GPI value is computed based on the data of the first 72 h; etc. For the majority of the patients, a decreasing GPI trend was observed.