Table 5 Thromboembolic events in placebo-controlled studies for the prophylaxis of bleeding with rFVIIa in surgical interventions
Reference | Operation | Number of events/patients | Odds ratio (95% CI) | |
|---|---|---|---|---|
Placebo | rFVIIa | |||
Levy et al. [51] (2006) | Dental operation | 0/9 | 0/30 | - |
Raobaikady et al. [52] (2005) | Pelvic-acetabular surgery | 0/24 | 0/24 | - |
Friederich et al. [3] (2003) | Prostatectomy | 0/12 | 0/24 | - |
Lodge et al. [2] (2005) | Partial hepatectomy | 3/68 | 6/132 | 0.97 (0.23–4.00) |
Shao et al. [53] (2006) | Partial hepatectomy | 1/81 | 3/151 | 0.62 (0.06–6.03) |
Planinsic et al. [54] (2005) | Liver transplantation | 3/19 | 8/64 | 1.53 (0.35–6.59) |
Lodge et al. [55] (2005) | Liver transplantation | 6/62 | 19/121 | 0.58 (0.22–1.52) |
Diprose et al. [56] (2005) | Cardiopulmonary bypass | 2/10 | 2/9 | 0.88 (0.10–7.95) |
Sum | 15/285 | 38/555 | ||
Weighted sum | 5.97 (0.85–11.1) | 6.42 (1.08–11.75) | 0.806 (0.42–1.53) | |