Reference(s) | Total number of cases | Patients undergoing abdominal surgery without known pre-existing coagulopathy | rFVIIa dose | Reduction or cessation of bleeding after rFVIIa | Survivors | |
---|---|---|---|---|---|---|
Number | Indication for rFVIIa | |||||
O'Connell et al. [11] (2003) and Laffan et al. [34] (2005) | 40 | 11 | Severe bleeding in patients undergoing colectomy (n = 4), operation of aortic aneurysm (n = 3), splenectomy (n = 2), intestinal resection (n = 1), resection of pseudocyst of pancreas (n = 1) | No information about subgroup | 10/11 | Not reported |
Clark et al. [9] (2004) | 10 | 4 | Uncontrollable bleeding and after more than 15 packed red blood cells in elective operation of abdominal aortic aneurysm (n = 3) and after prostatectomy (n = 1) | 1 × 7.2 mg (n = 3: 90, 101, and 97 μg/kg) 2 × 7.2 mg (90 μg/kg) | 1/4 | 0/4 |
Mayo et al. [15] (2004) | 13 | 4 | Uncontrollable, life-threatening bleeding after operation of pancreas carcinoma (n = 2) or gastric carcinoma (n = 1) and cholecystectomy (n = 1) | Protocol: 7.2 mg (67.5 to 90 μg/kg), up to two more doses of 2.4 mg | 3/4 | 3/4 |
Aggarwal et al. [18] (2004) | 40 | 1 | Uncontrollable bleeding in a patient with colectomy | 2 × 90 μg/kg | 0/1 | 0/1 |
Manning et al. [10] (2005) | 8 | 6 | Uncontrollable bleeding in vascular surgery interventions: aortic aneurysm (n = 5) and infected aortic prosthesis (n = 1) | 1 × 40 μg/kg (n = 4) 2 × 40 μg/kg (n = 2) | 5/6 | 4/6 |
Vilstrup et al. [26] (2006) | 11 | 1 | Intraoperative bleeding during operation of peptic duodenal ulcer | 1 × 33.3 μg/kg | 1/1 | 1/1 |
Haas et al. [25] (2005) | 5 | 2 | Uncontrollable bleeding in patients with ruptured venous malformation (n = 1) and after laparoscopic cholecystectomy (n = 1) | 1) 1 × 120 μg/kg 2) 1 × 80 μg/kg | 2/2 | 2/2 |
Filan et al. [29] (2005) | 4 | 4 | Uncontrollable liver bleeding in premature infants with laparotomy due to necrotizing enterocolitis (n = 4) | 1) 2 × 100 μg/kg 2) 1 × 90 μg/kg 3) 2 × 300 μg/kg 4) 2 × 400 μg/kg | 3/4 | 2/4 |
Biss et al. [12] (2006) | 36 | 8 | Uncontrollable bleeding in surgical patients with abdominal aortic aneurysm (n = 4), splenectomy (n = 2), ischemic bowel (n = 1), liver hematoma postcholecystectomy (n = 1) | 3 × 30 μg/kg (n = 1) 1 × 90 μg/kg (n = 3) 2 × 90 μg/kg (n = 2) 3 × 90 μg/kg (n = 1) 5 × 90 μg/kg (n = 1) | 5/8 | 2/8 |
Grounds et al. [13] (2006) | 45 | 9 | Intra- or postoperative bleeding in surgical patients with resection of sigma, liver hemangioma, liver rupture, prostatectomy, kidney transplantation, ileocolic anastomosis, endoscopic retrograde cholangiopancreaticography, morbid obesity, duodenopancreatectomy | No detailed information about subgroup | 9/9 | 6/9 |
Total | 212 | 50 | 39/50 | 20/39 | ||
Estimated mean effect | 73.2% (51.0%–95.4%) | 53.0% (26.4%–79.7%) |