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Table 1

From: Effects of melatonin in an experimental model of ventilator-induced lung injury

  Control, placebo Control, melatonin PIP 15 cmH2O, placebo PIP 15 cmH2O, melatonin PIP 25 cmH2O, placebo PIP 25 cmH2O, melatonin
PaO2/FiO2 349 ± 38 441 ± 61 333 ± 49 322 ± 54 127 ± 14#,† 380 ± 86*
Histological score 0.8 ± 1.3 1 ± 1.6 1.9 ± 2.8 2.1 ± 1.8 6.3 ± 3.3 2.7 ± 3.1
IL-10 (pg/mg protein) 221 ± 156 438 ± 236 208 ± 102 513 ± 202* 123 ± 191 457 ± 270*
Malondialdehyde (nmol/mg protein) 7 ± 1.5 7.5 ± 0.9 8.8 ± 2.1 7.3 ± 1.1 10.1 ± 3.4 13.8 ± 3.4#,†,*
  1. Data are mean ± SEM. P < 0.05 compared with #control, PIP 15 cmH2O or *melatonin.