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Table 1

From: Effects of melatonin in an experimental model of ventilator-induced lung injury

 

Control, placebo

Control, melatonin

PIP 15 cmH2O, placebo

PIP 15 cmH2O, melatonin

PIP 25 cmH2O, placebo

PIP 25 cmH2O, melatonin

PaO2/FiO2

349 ± 38

441 ± 61

333 ± 49

322 ± 54

127 ± 14#,†

380 ± 86*

Histological score

0.8 ± 1.3

1 ± 1.6

1.9 ± 2.8

2.1 ± 1.8

6.3 ± 3.3

2.7 ± 3.1

IL-10 (pg/mg protein)

221 ± 156

438 ± 236

208 ± 102

513 ± 202*

123 ± 191

457 ± 270*

Malondialdehyde (nmol/mg protein)

7 ± 1.5

7.5 ± 0.9

8.8 ± 2.1

7.3 ± 1.1

10.1 ± 3.4

13.8 ± 3.4#,†,*

  1. Data are mean ± SEM. P < 0.05 compared with #control, † PIP 15 cmH2O or *melatonin.
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Critical Care

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