Figure 7From: Fibrinogen decreases cardiomyocyte contractility through an ICAM-1-dependent mechanismFibrinogen subunit D decreases contractility. (a) Schematic diagram of the fibrinogen molecule, showing two D chains each containing a gamma chain linked to a central E chain. (b) Cardiomyocytes were incubated with whole fibrinogen as well as the major subunits D and E of fibrinogen. Whole fibrinogen and subunit D resulted in significant decreases in fractional shortening (FS), whereas subunit E had no significant effect. *,†p < 0.05 versus control.Back to article page