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Figure 2 | Critical Care

Figure 2

From: Fibrinogen decreases cardiomyocyte contractility through an ICAM-1-dependent mechanism

Figure 2

LPS increases intracardiac ICAM-1 and perivascular fibrinogen. (a) Frozen cardiac sections from lipopolysaccharide (LPS)-treated and saline-treated rats demonstrate that intracardiac intracellular adhesion molecule-1 (ICAM-1) (red) is dramatically increased in the former. (b) Fibrinogen (green) was greatly increased outside the endothelium (von Willebrand factor labeled red) in the LPS group compared with rats treated with saline. (c) Group mean data of the fold increases in myocardial ICAM-1 expression and perivascular fibrinogen deposition in LPS-treated versus saline-treated animals. *p < 0.05 versus saline.

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