Table 1 Antimicrobial Treatment for C. difficile-associated disease based on disease severity
From: Bench-to-bedside review: Clostridium difficile colitis
Disease classification | Recommended treatment |
|---|---|
Mild to moderate disease (mild to moderate diarrhea, leukocytosis <15,000/μl) | Metronidazole 500 mg orally 3 times/day for 10 to 14 days |
Severe disease (fever, profuse diarrhea, abdominal pain, leukocytosis ≥15,000/μl, elevated creatinine) | Vancomycin 125 to 500 mg orally 4 times/day for 10 to 14 days |
Severe disease, complicated (hypotension, shock, toxic megacolon, ileus) | Vancomycin 500 mg enterally by nasogastric tube and/or rectal enema 4 times/day with or without intravenous metronidazole 500 mg every 8 hours |