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Table 1 Antimicrobial Treatment for C. difficile-associated disease based on disease severity

From: Bench-to-bedside review: Clostridium difficile colitis

Disease classification Recommended treatment
Mild to moderate disease (mild to moderate diarrhea, leukocytosis <15,000/μl) Metronidazole 500 mg orally 3 times/day for 10 to 14 days
Severe disease (fever, profuse diarrhea, abdominal pain, leukocytosis ≥15,000/μl, elevated creatinine) Vancomycin 125 to 500 mg orally 4 times/day for 10 to 14 days
Severe disease, complicated (hypotension, shock, toxic megacolon, ileus) Vancomycin 500 mg enterally by nasogastric tube and/or rectal enema 4 times/day with or without intravenous metronidazole 500 mg every 8 hours
  1. Adapted using data from [6,43,44,54,56,79,92].