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Table 1 Systemic hemodynamics and metabolic variables during infusion of vasopressin

From: Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow

Time   300 minutes 360 minutes 480 minutes
Heart rate (beats per minute)a,b     
  Group C 126 ± 24 131 ± 26 136 ± 29
  Group V 125 ± 15 90 ± 8c 104 ± 14c
  Group S 120 ± 23 135 ± 26d 155 ± 29c
  Group SV 126 ± 10 106 ± 21c 117 ± 22
Mean arterial blood pressure (mm Hg)a,b     
  Group C 80 ± 12 80 ± 13 77 ± 13
  Group V 80 ± 9 97 ± 9c 100 ± 11c
  Group S 68 ± 9 67 ± 9 67 ± 7
  Group SV 74 ± 9 100 ± 22c 95 ± 20c
Cardiac index (mL/kg per minute)a,b     
  Group C 148 ± 31 147 ± 33 149 ± 34
  Group V 147 ± 27 96 ± 13c 118 ± 12d
  Group S 174 ± 22 166 ± 20 179 ± 14
  Group SV 168 ± 47 107 ± 13c 125 ± 27c
PAOP (mm Hg)a,e     
  Group C 6 ± 1 7 ± 1 6 ± 1
  Group V 6 ± 1 8 ± 1d 8 ± 2c
  Group S 8 ± 1 6 ± 1 6 ± 2
  Group SV 6 ± 1 6 ± 2 6 ± 2
Arterial pH     
  Group C 7.45 ± 0.03 7.45 ± 0.03 7.44 ± 0.04
  Group V 7.44 ± 0.02 7.44 ± 0.04 7.44 ± 0.05
  Group S 7.43 ± 0.02 7.44 ± 0.02 7.43 ± 0.02
  Group SV 7.43 ± 0.04 7.43 ± 0.04 7.43 ± 0.04
Arterial standard base excess (mmol/L)     
  Group C 3.9 ± 1.4 3.6 ± 1.5 3.3 ± 1.8
  Group V 2.4 ± 1.6 2.9 ± 1.9 2.9 ± 2.2
  Group S 3.1 ± 0.9 3.7 ± 0.5 3.2 ± 0.9
  Group SV 2.2 ± 1.2 3.0 ± 1.2 2.7 ± 1.5
Arterial lactate concentration (mmol/L)     
  Group C 0.99 ± 0.15 0.96 ± 0.12 0.95 ± 0.17
  Group V 0.98 ± 0.12 1.10 ± 0.24 1.11 ± 0.26d
  Group S 1.36 ± 0.48 1.11 ± 0.31c 1.10 ± 0.30c
  Group SV 1.46 ± 0.25 1.25 ± 0.17c 1.20 ± 0.16c
Arterial oxygen partial pressure (mm Hg)f     
  Group C 162 ± 19 156 ± 21 152 ± 25
  Group V 161 ± 16 143 ± 29d 141 ± 21
  Group S 163 ± 17 163 ± 16 161 ± 19
  Group SV 165 ± 10 157 ± 21 160 ± 13
Mixed venous oxygen saturation (percentage)a,b,e     
  Group C 66 ± 5 65 ± 6 66 ± 5
  Group V 64 ± 10 42 ± 10c 49 ± 11c
  Group S 59 ± 5 59 ± 5 61 ± 5
  Group SV 61 ± 6 53 ± 7c 58 ± 7
DO2I sys (mL/kg per minute)a,b     
  Group C 18 ± 2.6 18 ± 2.7 19 ± 2.8
  Group V 16 ± 2.8 9.4 ± 1.9c 11 ± 1.8d
  Group S 17 ± 2.1 18 ± 3.3 20 ± 2.8
  Group SV 19 ± 5.5 13 ± 2.2c 15 ± 3.6
VO2I sys (mL/kg per minute)     
  Group C 6.1 ± 0.8 6.0 ± 1.1 6.2 ± 1.1
  Group V 5.7 ± 0.7 5.6 ± 1.2 5.7 ± 1.1
  Group S 7.3 ± 1.3 7.3 ± 1.5 7.7 ± 0.5
  Group SV 7.5 ± 1.8 6.0 ± 0.9d 6.2 ± 1.1
Urinary output (mL/kg per hour)     
  Group C 2.1 ± 2.4 2.3 ± 2.4 1.8 ± 2.2
  Group V 1.6 ± 0.8 3.8 ± 2.2 5.4 ± 3.9d
  Group S 1.4 ± 0.9 1.9 ± 1.4 0.9 ± 0.5
  Group SV 1.0 ± 0.5 3.5 ± 3.2 2.6 ± 2.0
  1. In groups V and SV, a continuous infusion of vasopressin (0.06 IU/kg per hour) was started at t = 300 minutes. Groups C and S received intravenous crystalloids only.
  2. ap < 0.05 time-group interaction groups V versus C: effect of vasopressin in control animals.
  3. bp < 0.01 time-group interaction groups SV versus S: effect of vasopressin in septic animals.
  4. cp < 0.01 compared to t = 300 minutes.
  5. dp < 0.05 compared to t = 300 minutes.
  6. ep < 0.01 Mann-Whitney test (area under curve): effect of vasopressin in non-septic versus septic animals.
  7. fp < 0.05 time-group interaction groups SV versus S: effect of vasopressin in septic animals.
  8. DO2I sys: systemic oxygen delivery index. Group C: non-septic control group. Group S: septic control group. Group SV: septic test group treated with vasopressin. Group V: non-septic vasopressin control group. PAOP: pulmonary artery occlusion pressure. VO2I sys: systemic oxygen consumption index.