Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow

Krejci, Vladimir; Hiltebrand, Luzius B; Jakob, Stephan M; Takala, Jukka; Sigurdsson, Gisli H

doi:10.1186/cc6197

Critical Care

Table 1 Systemic hemodynamics and metabolic variables during infusion of vasopressin

From: Vasopressin in septic shock: effects on pancreatic, renal, and hepatic blood flow

Time		300 minutes	360 minutes	480 minutes
Heart rate (beats per minute)^a,b
	Group C	126 ± 24	131 ± 26	136 ± 29
	Group V	125 ± 15	90 ± 8^c	104 ± 14^c
	Group S	120 ± 23	135 ± 26^d	155 ± 29^c
	Group SV	126 ± 10	106 ± 21^c	117 ± 22
Mean arterial blood pressure (mm Hg)^a,b
	Group C	80 ± 12	80 ± 13	77 ± 13
	Group V	80 ± 9	97 ± 9^c	100 ± 11^c
	Group S	68 ± 9	67 ± 9	67 ± 7
	Group SV	74 ± 9	100 ± 22^c	95 ± 20^c
Cardiac index (mL/kg per minute)^a,b
	Group C	148 ± 31	147 ± 33	149 ± 34
	Group V	147 ± 27	96 ± 13^c	118 ± 12^d
	Group S	174 ± 22	166 ± 20	179 ± 14
	Group SV	168 ± 47	107 ± 13^c	125 ± 27^c
PAOP (mm Hg)^a,e
	Group C	6 ± 1	7 ± 1	6 ± 1
	Group V	6 ± 1	8 ± 1^d	8 ± 2^c
	Group S	8 ± 1	6 ± 1	6 ± 2
	Group SV	6 ± 1	6 ± 2	6 ± 2
Arterial pH
	Group C	7.45 ± 0.03	7.45 ± 0.03	7.44 ± 0.04
	Group V	7.44 ± 0.02	7.44 ± 0.04	7.44 ± 0.05
	Group S	7.43 ± 0.02	7.44 ± 0.02	7.43 ± 0.02
	Group SV	7.43 ± 0.04	7.43 ± 0.04	7.43 ± 0.04
Arterial standard base excess (mmol/L)
	Group C	3.9 ± 1.4	3.6 ± 1.5	3.3 ± 1.8
	Group V	2.4 ± 1.6	2.9 ± 1.9	2.9 ± 2.2
	Group S	3.1 ± 0.9	3.7 ± 0.5	3.2 ± 0.9
	Group SV	2.2 ± 1.2	3.0 ± 1.2	2.7 ± 1.5
Arterial lactate concentration (mmol/L)
	Group C	0.99 ± 0.15	0.96 ± 0.12	0.95 ± 0.17
	Group V	0.98 ± 0.12	1.10 ± 0.24	1.11 ± 0.26^d
	Group S	1.36 ± 0.48	1.11 ± 0.31^c	1.10 ± 0.30^c
	Group SV	1.46 ± 0.25	1.25 ± 0.17^c	1.20 ± 0.16^c
Arterial oxygen partial pressure (mm Hg)^f
	Group C	162 ± 19	156 ± 21	152 ± 25
	Group V	161 ± 16	143 ± 29^d	141 ± 21
	Group S	163 ± 17	163 ± 16	161 ± 19
	Group SV	165 ± 10	157 ± 21	160 ± 13
Mixed venous oxygen saturation (percentage)^a,b,e
	Group C	66 ± 5	65 ± 6	66 ± 5
	Group V	64 ± 10	42 ± 10^c	49 ± 11^c
	Group S	59 ± 5	59 ± 5	61 ± 5
	Group SV	61 ± 6	53 ± 7^c	58 ± 7
DO₂I sys (mL/kg per minute)^a,b
	Group C	18 ± 2.6	18 ± 2.7	19 ± 2.8
	Group V	16 ± 2.8	9.4 ± 1.9^c	11 ± 1.8^d
	Group S	17 ± 2.1	18 ± 3.3	20 ± 2.8
	Group SV	19 ± 5.5	13 ± 2.2^c	15 ± 3.6
VO₂I sys (mL/kg per minute)
	Group C	6.1 ± 0.8	6.0 ± 1.1	6.2 ± 1.1
	Group V	5.7 ± 0.7	5.6 ± 1.2	5.7 ± 1.1
	Group S	7.3 ± 1.3	7.3 ± 1.5	7.7 ± 0.5
	Group SV	7.5 ± 1.8	6.0 ± 0.9^d	6.2 ± 1.1
Urinary output (mL/kg per hour)
	Group C	2.1 ± 2.4	2.3 ± 2.4	1.8 ± 2.2
	Group V	1.6 ± 0.8	3.8 ± 2.2	5.4 ± 3.9^d
	Group S	1.4 ± 0.9	1.9 ± 1.4	0.9 ± 0.5
	Group SV	1.0 ± 0.5	3.5 ± 3.2	2.6 ± 2.0

In groups V and SV, a continuous infusion of vasopressin (0.06 IU/kg per hour) was started at t = 300 minutes. Groups C and S received intravenous crystalloids only.
^ap < 0.05 time-group interaction groups V versus C: effect of vasopressin in control animals.
^bp < 0.01 time-group interaction groups SV versus S: effect of vasopressin in septic animals.
^cp < 0.01 compared to t = 300 minutes.
^dp < 0.05 compared to t = 300 minutes.
^ep < 0.01 Mann-Whitney test (area under curve): effect of vasopressin in non-septic versus septic animals.
^fp < 0.05 time-group interaction groups SV versus S: effect of vasopressin in septic animals.
DO₂I sys: systemic oxygen delivery index. Group C: non-septic control group. Group S: septic control group. Group SV: septic test group treated with vasopressin. Group V: non-septic vasopressin control group. PAOP: pulmonary artery occlusion pressure. VO₂I sys: systemic oxygen consumption index.

Back to article page

ISSN: 1364-8535

Contact us

Submission enquiries: journalsubmissions@springernature.com