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Figure 4 | Critical Care

Figure 4

From: Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection

Figure 4

Delayed administration of the anti-RAGE antibody is protective in cecal ligation and puncture (CLP). The Kaplan-Meier survival analysis following CLP in BALB/c mice compares delayed anti-RAGE monoclonal antibody (mAb) treatment given at various time intervals after CLP with serum control. Each group had a significantly greater survival than the control group (P < 0.01), except for the 36-hour delayed treatment group (P = 0.12). RAGE, receptor for advanced glycation end products.

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