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Figure 3 | Critical Care

Figure 3

From: Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection

Figure 3

Lethality from cecal ligation and puncture (CLP) is decreased in BALB/c mice administered an anti-RAGE monoclonal antibody (mAb). The Kaplan-Meier survival analysis following CLP compares anti-RAGE mAb-treated animals given 7.5 mg/kg (n = 15) or 15 mg/kg (n = 15) intravenously 30 to 60 minutes before CLP with serum control animals (n = 15). The group given 15 mg/kg had a significantly greater survival than the group given 7.5 mg/kg (P < 0.05) or serum control (P < 0.001). RAGE, receptor for advanced glycation end products.

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