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Table 1 Targeted reactive oxygen species generation pathways

From: Platelet-derived exosomes from septic shock patients induce myocardial dysfunction

Inhibitor (final concentration) Pathway inhibited
Diphenylene iodonium (0.02 mM) Flavoenzymes, in particular NADPH oxidase
Indomethacin (0.1 mM) Cyclooxygenase
Apocynin (1 mM) NADPH oxidase
N-acetyl cysteine (3 mM) Anti-oxidant; thiol group donor
L-monomethyl-arginine (0.1 mM) Nitric oxide synthase