Table 1 Targeted reactive oxygen species generation pathways
From: Platelet-derived exosomes from septic shock patients induce myocardial dysfunction
Inhibitor (final concentration) | Pathway inhibited |
|---|---|
Diphenylene iodonium (0.02 mM) | Flavoenzymes, in particular NADPH oxidase |
Indomethacin (0.1 mM) | Cyclooxygenase |
Apocynin (1 mM) | NADPH oxidase |
N-acetyl cysteine (3 mM) | Anti-oxidant; thiol group donor |
L-monomethyl-arginine (0.1 mM) | Nitric oxide synthase |