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Figure 6 | Critical Care

Figure 6

From: Platelet-derived exosomes from septic shock patients induce myocardial dysfunction

Figure 6

Exosomes exhibit intrinsic nitric oxide (NO) production and induce myocardial NO production. (a) 4,5-diaminofluorescein-2 (DAF-2) fluorescence (an index of NO production) by exosomes from septic shock patients and healthy volunteers. Data are mean ± standard error of the mean (SEM) of six experiments with exosomes from healthy volunteers and septic patients. *p < 0.05 versus healthy; §p < 0.05 versus baseline healthy; #p < 0.05 versus baseline septic (one-way analysis of variance, Student-Newman-Keuls test). Black bars: baseline septic and healthy exosomes; gray bars: septic and healthy exosomes + superoxide dismutase (SOD) (250 IU/mL); white bars: septic and healthy exosomes + N(G)-nitro-L-arginine methyl ester (L-NAME) (100 μM). (b) Myocardial nitrate content of hearts exposed for 45 minutes to exosomes from septic patients or healthy volunteers. Data are mean ± SEM of four experiments for exosomes of septic patients and healthy volunteers. *p < 0.05 versus healthy (t test). RFU, relative fluorescence unit.

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