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Table 3 Part 2. Clinical outcomes of the controlled study

From: Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial

Variables Tranexamic acid (n = 24) Placebo (n = 26) P value
D-dimer at 0 hours, ng/mLa 448 (270–625) 1,069 (951–1,189) <0.01
D-dimer at 4 hours, ng/mL 499 (364–633) 974 (880–1,069) <0.01
D-dimer at 24 hours, ng/mL 433 (280–608) 976 (868–1,064) <0.01
Plasminogen activator inhibitor 1 at 4 hours, ng/mL 88 (35–140) 129 (70–188) 0.04
Creatine-kinase at 0 hours, U/L 261 (199–322) 327 (270–383) 0.03
Creatine-kinase MB at 0 hours, U/L 41 (35–47) 63 (50–77) <0.01
STNFR-1 at 4 hours, ng/mL 1,274 (958–1,590) 1,656 (1,175–2,138) 0.09
Interleukin-6 at 4 hours, pg/mL 236 (140–332) 362 (250–474) 0.12
Interleukin-6 at 24 hours, pg/mL 87 (61–114) 119 (88–151) 0.07
Twenty-four-hour bleeding, mL 464 (308–620) 1,037 (771–1,303) <0.01
Total bleeding, mL 835 (407–1,263) 1,466 (1,116–1,818) <0.01
RBCb units transfused within the first 4 hours (percentage)c 1 (4) 2 (7) 0.39
RBCb units until chest tube withdrawal (percentage)c 9 (38) 19 (73) 0.01
Plasma units until chest tube withdrawal (percentage)c 1 (4) 8 (31) 0.02
Inflammatory response after CPB, number (percentage) 4 (17) 11 (42) 0.047
Vasoplegic shock, number (percentage) 0 7 (27) <0.01
Norepinephrine, hours 1.2 (0.5–2.4) 25.4 (5.6–45) 0.02
Mechanical ventilation, hoursd 6.5 (5–13.5) 12 (7–24) 0.02
Intensive care unit stay, daysd 3 (2–5.5) 3.5 (2–5) 0.96
Postsurgical hospital stay, daysd 4.5 (3–6) 4 (2–5) 0.34
  1. Values are expressed as mean and 95% confidence interval or as frequency and percentage. a0 hours represents intensive care unit admission after cardiopulmonary bypass (CPB); btotal red blood cell (RBC) and plasma until chest tube withdrawal; cpercentage of transfused patients; dvalues are expressed as median and interquartile range. STNFR-1, soluble tumor necrosis factor receptor type 1.