From: Intentional overdose with insulin: prognostic factors and toxicokinetic/toxicodynamic profiles
Patient | Sex/age (years) | Diabetes | Insulin type/dose | Delay to initial therapy (hours) | Lowest blood glucose level (mmol/l) | Emax (g/h) | EC50 (mU/l) | Cmax (mIU/l) | R2 | T1/2 (hours) | Outcome |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | Male/60 | Type 1 | Rapid-acting/500 IU | 2.0 | 0.8 | 17.5 | 667 | 1,853 | 0.98 | 3.5 | Alive |
2 | Female/40 | Type 1 | 30% rapid-acting/70% slow-acting/120 IU | 0.8 | 0.8 | 36 | 35 | 151 | 0.91 | 4.0 | Alive |
3 | Female/52 | Type 2 | Slow-acting/1,500 IU | 2.6 | 2.0 | 119.9 | 42 | 704 | 0.71 | 11.7 | Alive |
4 | Female/45 | Nondiabetic | Rapid-acting/100 IU | 0.3 | 1.1 | 23.1 | 161 | 9,053 | 0.88 | 0.8 | Alive |
5 | Male/16 | Nondiabetic | Slow-acting/1,500 IU | 1.5 | 2.5 | 41.1 | 50 | 5,740 | 0.70 | 4.6 | Alive |
6 | Female/60 | Nondiabetic | Rapid-acting/1,200 IU | 1.0 | 1.7 | 14.6 | 12 | 197 | 0.79 | 1.5 | Alive |