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Figure 1 | Critical Care

Figure 1

From: Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis

Figure 1

Receptor of advanced glycation endproducts (RAGE)-mediated signal transduction. AGE, advanced glycation endproduct; C, C-type immunglobulin domain; ERK-1/2, extracellular signal-regulated kinase 1/2; HMGB1, high-mobility group box protein 1; ICAM-1, intercellular adhesion molecule 1; IκB, inhibitor of kappa B; IKK, inhibitor of kappa B kinase; JAK, Janus kinase; JNK, c-jun N-terminal kinase; MAC-1, macrophage-1 antigen; NF-κB, nuclear factor kappa B; P13K, phosphoinositide 3-kinase; ROS, reactive oxygen species; SAPK, stress-activated protein kinase; STAT, signal transducer and activator of transcription; V, V-type immunglobulin domain; VCAM-1, vascular cell adhesion molecule 1; VLA-4, very late antigen 4.

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