From: Improved survival of children with sepsis and purpura: effects of age, gender, and era
 | Before meningococcal C vaccinationa | After meningococcal C vaccinationa |
---|---|---|
Total number of children (%) | 248 | 39 |
 | (86.4) | (13.6) |
Case fatality (%) | 45b | 0b |
 | (18.1) | (0) |
Age in years | 3.2 | 2.5 |
 | (0.1 to 17.9) | (0.3 to 13.1) |
Number of children with DIC (%) | 186c | 20c |
 | (79.5) | (62.5) |
Number of PICU-free days | 24c | 25c |
 | (0 to 28) | (0 to 27) |
PRISM score | 15 | 20 |
 | (1 to 44) | (2 to 37) |
Predicted death rate (%)d | 5.6 | 8.1 |
 | (0 to 100) | (0 to 100) |
Base excess (mmol/L) | -7.7 | -8 |
 | (-28 to 4.4) | (-18 to -2) |
Lactate (mmol/L) | 4.1 | 4.0 |
   Geometric mean, 95% CI | 3.8 to 4.4 | 3.3 to 4.8 |
C-reactive protein (mg/L) | 93 | 84 |
 | (6 to 326) | (25 to 334) |
Fibrinogen (g/L) | 2.5 | 3.2 |
 | (0.2 to 6.8) | (0.3 to 6.4) |
Platelet count (×103/μL) | 110 | 135 |
 | (13 to 475) | (25 to 227) |
Leukocytes (×103/μL) | 8.9 | 12.1 |
   Geometric mean, 95% CI | 7.9 to 10.0 | 9.4 to 15.6 |
Glucose (mmol/L) | 5.7c | 7.2c |
   Geometric mean, 95% CI | 5.3 to 6.2 | 6.2 to 8.2 |