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Table 4 Comparison of disease characteristics between children with sepsis and purpura before and after the national meningococcal C vaccination campaign (July 2002)

From: Improved survival of children with sepsis and purpura: effects of age, gender, and era

  Before meningococcal C vaccinationa After meningococcal C vaccinationa
Total number of children (%) 248 39
  (86.4) (13.6)
Case fatality (%) 45b 0b
  (18.1) (0)
Age in years 3.2 2.5
  (0.1 to 17.9) (0.3 to 13.1)
Number of children with DIC (%) 186c 20c
  (79.5) (62.5)
Number of PICU-free days 24c 25c
  (0 to 28) (0 to 27)
PRISM score 15 20
  (1 to 44) (2 to 37)
Predicted death rate (%)d 5.6 8.1
  (0 to 100) (0 to 100)
Base excess (mmol/L) -7.7 -8
  (-28 to 4.4) (-18 to -2)
Lactate (mmol/L) 4.1 4.0
   Geometric mean, 95% CI 3.8 to 4.4 3.3 to 4.8
C-reactive protein (mg/L) 93 84
  (6 to 326) (25 to 334)
Fibrinogen (g/L) 2.5 3.2
  (0.2 to 6.8) (0.3 to 6.4)
Platelet count (×103/μL) 110 135
  (13 to 475) (25 to 227)
Leukocytes (×103/μL) 8.9 12.1
   Geometric mean, 95% CI 7.9 to 10.0 9.4 to 15.6
Glucose (mmol/L) 5.7c 7.2c
   Geometric mean, 95% CI 5.3 to 6.2 6.2 to 8.2
  1. aResults represent median (min-max) unless stated otherwise. bp < 0.01. cp < 0.05. dPredicted death rate was based on the Rotterdam score. CI, confidence interval; DIC, disseminated intravascular coagulation; PICU, paediatric intensive care unit; PRISM, Paediatric Risk of Mortality.