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Figure 6 | Critical Care

Figure 6

From: Platelet-derived exosomes induce endothelial cell apoptosis through peroxynitrite generation: experimental evidence for a novel mechanism of septic vascular dysfunction

Figure 6

Platelet-derived exosomes may generate peroxynitrite. The graph shows a decrease in 2',7'-dichlorofluorescein diacetate signals after the addition of L-arginine (1 mM), further suggesting a role for uncoupled nitric oxide synthase in superoxide generation. In contrast, the inhibitory effect of urate addition strongly suggests the involvement of peroxynitrite oxidation. Results are means ± SD of five experiments for each group. *P < 0.05 versus control, †P < 0.05 versus untreated. NONOate, diethylamine NONOate; RFU, relative fluorescence units.

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