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Table 1 Lung and hemodynamic parameters

From: Alveolar instability caused by mechanical ventilation initially damages the nondependent normal lung

  Baseline 15 minutes 30 minutes 45 minutes 60 minutes 75 minutes 90 minutes
Ventilation positive end-expiratory pressure 10 cmH2O (n = 10)
   PCO2 32.5 ± 4.40 35.7 ± 4.38 32.6 ± 4.73 31.2 ± 4.26* 28.2 ± 4.67 26.5 ± 4.21 24 ± 4.39
   PO2 239.6 ± 15.44 293.1 ± 17.18 300.6 ± 10.66 294.5 ± 17.62 292.5 ± 21.46 331.7 ± 1.79 333.8 ± 14.23
   Tidal volume (ml) 6.2 ± 0.55 3.8 ± 1.06* 3.1 ± 1.08* 3.1 ± 1.08* 2.4 ± 1.02* 2.5 ± 1.05* 2.5 ± 1.07*
   Lung static compliance (ml/cmH2O) 0.5 ± 0.03 0.19 ± 0.03* 0.53 ± 0.29 0.47 ± 0.23 0.35 ± 0.09 0.34 ± 0.09 0.61 ± 0.34
   Mean arterial pressure (mmHg) 88.5 ± 6.86 93.6 ± 14.90 87.1 ± 11.48 77.2 ± 10.75 77.8 ± 10.76 77.9 ± 10.36 58.1 ± 8.91
   Fluid totala        9.9 ± 2.88
Ventilation positive end-expiratory pressure 3 cmH2O (n = 9)
   PCO2 31 ± 3.67 26.4 ± 4.27 22.5 ± 2.17 17.8 ± 1.82 17.4 ± 2.34 18 ± 2.40 17.25 ± 3.26
   PO2 228.5 ± 24.91 293.4 ± 18.33 302.2 ± 17.62 289 ± 18.33 296.4 ± 20.85 290.78 ± 26.85 308.4 ± 32.11
   Tidal volume (ml) 6.9 ± 1.53 11.5 ± 1.01 11.9 ± 1.37 12.3 ± 1.16 12.1 ± 1.18 12.9 ± 1.25 11.7 ± 1.33
   Lung static compliance (ml/cmH2O) 0.47 ± 0.04 0.34 ± 0.02 0.32 ± 0.01 0.6 ± 0.27 0.74 ± 0.42 0.57 ± 0.25 0.53 ± 0.23
   Mean arterial pressure (mmHg) 88.2 ± 8.42 78.5 ± 6.81 83.1 ± 6.81 76.4 ± 4.36 83.1 ± 9.15 82.9 ± 9.21 76.4 ± 8.12
   Fluid totala        9.8 ± 2.74
  1. aTotal amount of normal saline infused over the entire experiment (ml). *P < 0.05 between groups.