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Table 1 Patient characteristics in the initial cohort

From: Cost-effectiveness of activated protein C in real-life clinical practice

Characteristic All patients (n = 1,096) Pre-license (n = 509) Post-license (n = 587) P
Demographics     
   Age (yrs) 60.8 ± 16.3 63.9 ± 15.1 58.1 ± 16.8 <0.0001
> 60 yrs 57.9 64.1 52.5 0.0001
   Male 62.0 61.5 62.5 0.7265
   Weight (kg) 73.9 ± 17.4 73.5 ± 17.3 74.2 ± 17.4 0.5546
Prior location     0.0702
   Medical or surgical department 40.4 44.0 37.3  
   Emergency department 28.4 27.1 29.5  
   Another acute care hospital 22.6 19.8 25.0  
   Home 8.6 9.1 8.2  
Reason for ICU admission     0.9168
   Medical 71.7 72.1 71.4  
   Surgical 27.0 26.5 27.4  
   Trauma 1.3 1.4 1.2  
Disease severity     
   SAPS II on admission 56.6 ± 18.6 56.9 ± 19.1 56.2 ± 18.1 0.5427
   LOD score at enrolmenta 7.67 ± 2.82 7.44 ± 2.93 7.87 ± 2.71 0.0112
   Organ failure at enrolmenta 3.21 ± 0.86 3.10 ± 0.86 3.31 ± 0.85 <0.0001
Acute lung injury 2.1 ± 1.1 1.9 ± 1.2 2.2 ± 1.0 <0.0001
Acute renal failure 3.4 ± 1.7 3.3 ± 1.8 3.4 ± 1.7 0.3777
Coagulopathy 0.3 ± 0.7 0.3 ± 0.6 0.3 ± 0.7 0.0629
Acute liver failure 0.3 ± 0.5 0.3 ± 0.5 0.3 ± 0.5 0.1831
Acute cardiovascular Failure 1.6 ± 1.3 1.7 ± 1.3 1.6 ± 1.2 0.4399
   Shock at enrolment 93.7 92.5 94.7 0.1375
Co-morbid conditions     
   McCabe     <0.0001
0 36.4 30.8 41.5  
1 35.9 34.2 37.5  
2 21.5 26.0 17.5  
3 6.1 9.0 3.6  
   Chronic renal failure 6.3 7.7 5.0 0.0649
   Chronic liver disease 4.2 4.4 4.1 0.8593
   Congestive cardiomyopathy 13.0 14.1 12.0 0.3018
   COPD 14.3 14.7 14.1 0.7824
   Diabetes mellitus 6.5 6.8 6.2 0.7123
   Immunosuppressive treatment 6.1 5.7 6.4 0.6653
   Chemotherapy 3.2 3.9 2.6 0.1982
   Metastatic cancer 5.0 6.4 3.8 0.0553
   Haematological malignancies 3.3 4.2 2.6 0.1450
   HIV 1.8 1.4 2.1 0.4018
Infection site     
   Lung 49.2 50.1 48.4 0.5867
   Intra-abdominal 26.2 27.6 25.0 0.3454
   Urinary tract 9.8 12.0 7.9 0.0273
   CNS 4.9 2.7 6.7 0.0032
  1. Values are expressed mean ± standard deviation or proportions of patients. aNeurological failure excluded. CNS, central nervous system; COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; LOD, Logistic Organ Dysfunction; SAPS, Simplified Acute Physiology Score.