Figure 5

Cytokine concentrations in relation to acute hospitalization. Cytokines were measured at admission (Admit), at first surgery (OR1), at 5–8 days postsurgery 1, at second surgery (OR2), at 5–8 days postsurgery 2, at third surgery (OR3), and again at 5–8 days postsurgery 3. Six cytokines out of 17 measured were significantly different between different burn sizes. Serum IL-8, TNF, IL-6, IL-12p70, monocyte chemoattractant protein-1 (MCP-1) and granulocyte–macrophage colony-stimulating factor (GM-CSF) were significantly increased in the large burns compared with the other three groups. *Significant difference between >80% TBSA burn group versus 60–79%, 40–59% and <40% TBSA burn groups, P < 0.05. ^†Significant difference between 60–79% TBSA burn group versus 40–79% and <40% TBSA burn groups, P < 0.05. ^‡Significant difference between 40–59% TBSA burn group versus <40% TBSA burn group, P < 0.05. Normal levels: IL-8, 7.6 ± 3.9 pg/ml; TNF, 0.7 ± 0.07 pg/ml; IL-6, 8.7 ± 4.9 pg/ml; IL-12p70, 0 ± 0 pg/ml; MCP-1, 42 ± 5 pg/ml; and GM-CSF, 0 ± 0 pg/ml.